mPGES1-IN-17d ( —— )

Catalog No. M12011 CAS No. 1469976-70-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

mPGES1-IN-17d
Note

Research use only, not for human use.
Brief Description

mPGES1-IN-17d is a potent, selective mPGES-1 inhibitor with enzyme IC50 of 8 nM, A549 cell IC50 of 16.24 nM.
Description

mPGES1-IN-17d is a potent, selective mPGES-1 inhibitor with enzyme IC50 of 8 nM, A549 cell IC50 of 16.24 nM, human whole blood IC50 of 249.9 nM; displays excellent in vitro selectivity over mPGES-2, cPGES, COX1/2, other prostanoid synthases, favorable hERG and CEREP panel profile; shows good efficacy in LPS-induced thermal hyperalgesia pain model; demonstrates good oral pharmacokinetic profiles and good CNS B/P ratio in rat and guinea pig.
Synonyms

——
Pathway

Immunology/Inflammation
Target

PGE synthase
Recptor

PGE synthase
Research Area

——
Indication

——

CAS Number

1469976-70-2
Formula Weight

538.86
Molecular Formula

C24H16ClF5N4O3
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(NC1=CC(F)=CC(C(F)(F)F)=C1)C2=C(OCCO3)C3=C(N(C)C(NC4=C(Cl)C=CC=C4F)=N5)C5=C2
Chemical Name

2-((2-chloro-6-fluorophenyl)amino)-N-(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-7,8-dihydro-1H-[1,4]dioxino[2',3':3,4]benzo[1,2-d]imidazole-5-carboxamide

1. Muthukaman N, et al. Bioorg Med Chem Lett. 2016 Dec 15;26(24):5977-5984.

Calculator

molnova catalog