kb-NB142-70

CAS No. 1233533-04-4

kb-NB142-70( kb NB 142-70 | kb NB142-70 | kb NB-142-70 )

Catalog No. M10925 CAS No. 1233533-04-4

kb-NB142-70 is a potent and selective PKD inhibitor with IC50 of 28.3 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 52 In Stock
5MG 86 In Stock
10MG 140 In Stock
25MG 314 In Stock
50MG 494 In Stock
100MG 709 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    kb-NB142-70
  • Note
    Research use only, not for human use.
  • Brief Description
    kb-NB142-70 is a potent and selective PKD inhibitor with IC50 of 28.3 nM.
  • Description
    kb-NB142-70 is a potent and selective PKD inhibitor with IC50 of 28.3 nM; displays 10-fold increase in the in vitro PKD1 inhibitory potency versus CID755673; inhibits PC-3, PANC-1, CFPAC-1 cellular growth with IC50 of 5-30 uM.
  • In Vitro
    kb NB 142-70 is a potent PKD inhibitor, with IC50s of 28.3, 58.7 and 53.2 nM for PKD1, PKD2, and PKD3, respectively. kb NB 142-70 also inhibits Ser916 phosphorylation of PKD1 (IC50, 2.2 ± 0.6 μM) in LNCaP cells. Moreover, kb NB 142-70 is cytotoxic against PC3 cells with an EC50 of 8.025 μM. kb NB 142-70 (0-5 μM) concentration-dependently prevents ANG II-induced phosphorylation of HDAC4 at Ser246 and Ser632, HDAC5 at Ser259 and Ser498, and HDAC7 at Ser155 in IEC-18 cells. In addition, kb NB 142-70 (3.5 μM) also suppresses HDAC4, HDAC5, and HDAC7 phosphorylation in IEC-18 cells stimulated with ANG II for 0-240 min or with vasopressin, lysophosphatidic acid (LPA), or phorbol 12,13-dibutyrate (PDBu).
  • In Vivo
    ——
  • Synonyms
    kb NB 142-70 | kb NB142-70 | kb NB-142-70
  • Pathway
    Apoptosis
  • Target
    PKD
  • Recptor
    PKD1|PKD2|PKD3
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1233533-04-4
  • Formula Weight
    251.318
  • Molecular Formula
    C11H9NO2S2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 25.13 mg/mL (100 mM) ( < 1 mg/ml refers to the product slightly soluble or insoluble )
  • SMILES
    O=C1NCCSC2=C1SC3=CC=C(O)C=C32
  • Chemical Name
    3,4-dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bravo-Altamirano K, et al. ACS Med Chem Lett. 2011 Feb 14;2(2):154-159. 2. Guo J, et al. Cancer Chemother Pharmacol. 2013 Feb;71(2):331-44.
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  • kb-NB142-70

    kb-NB142-70 is a potent and selective PKD inhibitor with IC50 of 28.3 nM.