
kb-NB142-70
CAS No. 1233533-04-4
kb-NB142-70( kb NB 142-70 | kb NB142-70 | kb NB-142-70 )
Catalog No. M10925 CAS No. 1233533-04-4
kb-NB142-70 is a potent and selective PKD inhibitor with IC50 of 28.3 nM.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 52 | In Stock |
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5MG | 86 | In Stock |
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10MG | 140 | In Stock |
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25MG | 314 | In Stock |
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50MG | 494 | In Stock |
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100MG | 709 | In Stock |
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200MG | Get Quote | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product Namekb-NB142-70
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NoteResearch use only, not for human use.
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Brief Descriptionkb-NB142-70 is a potent and selective PKD inhibitor with IC50 of 28.3 nM.
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Descriptionkb-NB142-70 is a potent and selective PKD inhibitor with IC50 of 28.3 nM; displays 10-fold increase in the in vitro PKD1 inhibitory potency versus CID755673; inhibits PC-3, PANC-1, CFPAC-1 cellular growth with IC50 of 5-30 uM.
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In Vitrokb NB 142-70 is a potent PKD inhibitor, with IC50s of 28.3, 58.7 and 53.2 nM for PKD1, PKD2, and PKD3, respectively. kb NB 142-70 also inhibits Ser916 phosphorylation of PKD1 (IC50, 2.2 ± 0.6 μM) in LNCaP cells. Moreover, kb NB 142-70 is cytotoxic against PC3 cells with an EC50 of 8.025 μM. kb NB 142-70 (0-5 μM) concentration-dependently prevents ANG II-induced phosphorylation of HDAC4 at Ser246 and Ser632, HDAC5 at Ser259 and Ser498, and HDAC7 at Ser155 in IEC-18 cells. In addition, kb NB 142-70 (3.5 μM) also suppresses HDAC4, HDAC5, and HDAC7 phosphorylation in IEC-18 cells stimulated with ANG II for 0-240 min or with vasopressin, lysophosphatidic acid (LPA), or phorbol 12,13-dibutyrate (PDBu).
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In Vivo——
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Synonymskb NB 142-70 | kb NB142-70 | kb NB-142-70
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PathwayApoptosis
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TargetPKD
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RecptorPKD1|PKD2|PKD3
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1233533-04-4
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Formula Weight251.318
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Molecular FormulaC11H9NO2S2
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Purity>98% (HPLC)
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SolubilityDMSO: 25.13 mg/mL (100 mM) ( < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESO=C1NCCSC2=C1SC3=CC=C(O)C=C32
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Chemical Name3,4-dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Bravo-Altamirano K, et al. ACS Med Chem Lett. 2011 Feb 14;2(2):154-159.
2. Guo J, et al. Cancer Chemother Pharmacol. 2013 Feb;71(2):331-44.
molnova catalog



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kb-NB142-70
kb-NB142-70 is a potent and selective PKD inhibitor with IC50 of 28.3 nM.