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c-Kit-IN-1

CAS No. 1225278-16-9

c-Kit-IN-1( —— )

Catalog No. M17203 CAS No. 1225278-16-9

DCC-2618 is an effective inhibitor of c-Met and c-Kit (IC50s<200 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    c-Kit-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    DCC-2618 is an effective inhibitor of c-Met and c-Kit (IC50s<200 nM).
  • Description
    DCC-2618 is an effective inhibitor of c-Met and c-Kit (IC50s<200 nM).(In Vitro):c-Kit-IN-1 is a c-Kit and c-Met inhibitor extracted from patent 2010051373A1, compound example 45, has an IC50 of <200 nM. c-Kit-IN-1 also inhibits KDR, PDGFR α and β with IC50s of <2 μM, <10 μM and <10 μM, respectively.
  • In Vitro
    c-Kit-IN-1 is a c-Kit and c-Met inhibitor extracted from patent 2010051373A1, compound example 45, has an IC50 of <200 nM. c-Kit-IN-1 also inhibits KDR, PDGFR α and β with IC50s of <2 μM, <10 μM and <10 μM, respectively.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    CaMK
  • Recptor
    c-Kit| c-Met
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1225278-16-9
  • Formula Weight
    489.47
  • Molecular Formula
    C26H21F2N5O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 100 mg/mL. 204.30 mM
  • SMILES
    Cn1cc(cn1)c1nccc(c1)Oc1c(cc(c(c1)F)NC(=O)C1(CC1)C(=O)Nc1ccccc1)F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Daniel L. Flynn, et al. Cyclopropane amides and analogs exhibiting anti-cancer and anti-proliferative activities. WO 2010051373 A1
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