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alpha-Tocopherolquinone

CAS No. 7559-04-8

alpha-Tocopherolquinone( A-0001 | EPI-A-0001 | Vitamin E Quinone (D-form) )

Catalog No. M17740 CAS No. 7559-04-8

During hypoxia in rats, levels of α-tocopherylquinon have been found to rise. It is reported to downregulate the respiratory activity of mitochondria.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    alpha-Tocopherolquinone
  • Note
    Research use only, not for human use.
  • Brief Description
    During hypoxia in rats, levels of α-tocopherylquinon have been found to rise. It is reported to downregulate the respiratory activity of mitochondria.
  • Description
    ɑ-Tocopherolquinone, also known as Vitamin E Quinone (D-form), is a mitochondrial membrane transport protein that has been in phase II clinical trials for the treatment of inherited mitochondrial respiratory chain diseases, however this research has been discontinued. It has also been used for the treatment of Frederich's ataxia and MEILAS syndrome.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    A-0001 | EPI-A-0001 | Vitamin E Quinone (D-form)
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    7559-04-8
  • Formula Weight
    446.71
  • Molecular Formula
    C29H50O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (111.93 mM)
  • SMILES
    CC1=C(C(=O)C(=C(C1=O)C)CC[C@@](C)(CCC[C@H](C)CCC[C@H](C)CCCC(C)C)O)C
  • Chemical Name
    ɑ-2-(3-Hydroxy-3,7,11,15-tetramethylhexadecyl)-3,5,6-trimethyl-p-benzoquinone

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Siegel D, et al. The Reduction of α-Tocopherolquinone by Human NAD(P)H:Quinone Oxidoreductase: The Role of α-Tocopherolhydroquinone as a Cellular Antioxidant[J]. Molecular Pharmacology, 1997, 52(2):300-305.
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