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Zotizalkib

CAS No. 2648641-36-3

Zotizalkib( —— )

Catalog No. M37625 CAS No. 2648641-36-3

Zotizalkib (TPX-0131) is an orally active and selective ALK inhibitor with antitumor activity for the study of non-small cell lung cancer.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Zotizalkib
  • Note
    Research use only, not for human use.
  • Brief Description
    Zotizalkib (TPX-0131) is an orally active and selective ALK inhibitor with antitumor activity for the study of non-small cell lung cancer.
  • Description
    Zotizalkib (TPX-0131) is a potent, selective, CNS-penetrant and orally active inhibitor of wild-type ALK (IC50 of 1.4 nM) and ALK-resistant mutation, e.g. G1202R (IC50 of 0.3 nM), L1196M (IC50 of 0.3 nM). Zotizalkib has strong antitumor activities.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Female SCID/beige mice (5-8 weeks old) bearing Ba/F3 cells Dosage:2 mg/kg, 5 mg/kg, and 10 mg/kg Administration:p.o.; twice a day; for 2 weeks Result:Caused complete tumor regression in ALK mutation-dependent xenograft models.
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    ALK
  • Recptor
    ALK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2648641-36-3
  • Formula Weight
    447.41
  • Molecular Formula
    C21H20F3N5O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 62.5 mg/mL (139.69 mM; Ultrasonic (<80°C)
  • SMILES
    C(F)(F)[C@H]1N2C=3C(=CN4C(N3)=C(C=N4)C(=O)NC(C)(C)COC=5C(C2)=CC(F)=CC5)OC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Brion W Murray, et al. TPX-0131, a Potent CNS-Penetrant, Next-Generation Inhibitor of Wild-Type ALK and ALK-Resistant Mutations. Mol Cancer Ther. 2021 Jun 22;molcanther.0221.2021.?
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