Z-LEHD-fmk

CAS No. 210345-04-3

Z-LEHD-fmk( —— )

Catalog No. M33765 CAS No. 210345-04-3

Z-LEHD-FMK is a selective and potent caspase-9 inhibitor that protects against reperfusion injury and slows apoptosis. Z-LEHD-FMK exhibits antitumor and neuroprotective activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 301 Get Quote
5MG 588 Get Quote
10MG 833 Get Quote
25MG 1178 Get Quote
50MG 1610 Get Quote
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Biological Information

  • Product Name
    Z-LEHD-fmk
  • Note
    Research use only, not for human use.
  • Brief Description
    Z-LEHD-FMK is a selective and potent caspase-9 inhibitor that protects against reperfusion injury and slows apoptosis. Z-LEHD-FMK exhibits antitumor and neuroprotective activity.
  • Description
    Z-LEHD-FMK is a selective and irreversible inhibitor of caspase-9, protects against lethal reperfusion injury and attenuates apoptosis. Z-LEHD-FMK exhibits the neuroprotective effect in a rat model of spinal cord trauma.
  • In Vitro
    Z-LEHD-FMK (20 μM; pretreated for 30 min) completely protects HCT116 and 293 cells from TRAIL-induced toxicity.Z-LEHD-FMK (20 μM ; 6 h) protects normal human hepatocytes from TRAIL-induced apoptosis.Apoptosis Analysis Cell Line:SW480, H460, HCT116 and 293 cells Concentration:20 μM Incubation Time:Pretreated for 30 min Result:Protected HCT116 and 293 cells from TRAIL-induced apoptosis.Western Blot Analysis Cell Line:HCT116, SW480 cells Concentration:20 μM Incubation Time:2 h Result:Protected procaspase 3 from cleavage in HCT116 cells but not in SW480 cells, especially at the 16-h time point.
  • In Vivo
    Z-LEHD-FMK (0.8 μmol/kg; i.v. for 7 d) protects neurons, glia, myelin, axons, and intracellular organelles in spinal cord injury (SCI) rats.Animal Model:Male Wistar albino rats (250-350 g) with SCI Dosage:0.8 μmol/kg Administration:I.v. for 1 or 7 days Result:Decreased the mean apoptotic cell count at 24 hours and 7 days postinjury.
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Caspase
  • Recptor
    Caspase | Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    210345-04-3
  • Formula Weight
    690.72
  • Molecular Formula
    C32H43FN6O10
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (144.78 mM)
  • SMILES
    COC(=O)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(=O)OC)C(=O)CF
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ozoren N, et, al. The caspase 9 inhibitor Z-LEHD-FMK protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand. Cancer Res. 2000 Nov 15; 60(22): 6259-65.?
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