
Z-LEHD-fmk
CAS No. 210345-04-3
Z-LEHD-fmk( —— )
Catalog No. M33765 CAS No. 210345-04-3
Z-LEHD-FMK is a selective and potent caspase-9 inhibitor that protects against reperfusion injury and slows apoptosis. Z-LEHD-FMK exhibits antitumor and neuroprotective activity.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 301 | Get Quote |
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5MG | 588 | Get Quote |
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10MG | 833 | Get Quote |
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25MG | 1178 | Get Quote |
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50MG | 1610 | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameZ-LEHD-fmk
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NoteResearch use only, not for human use.
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Brief DescriptionZ-LEHD-FMK is a selective and potent caspase-9 inhibitor that protects against reperfusion injury and slows apoptosis. Z-LEHD-FMK exhibits antitumor and neuroprotective activity.
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DescriptionZ-LEHD-FMK is a selective and irreversible inhibitor of caspase-9, protects against lethal reperfusion injury and attenuates apoptosis. Z-LEHD-FMK exhibits the neuroprotective effect in a rat model of spinal cord trauma.
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In VitroZ-LEHD-FMK (20 μM; pretreated for 30 min) completely protects HCT116 and 293 cells from TRAIL-induced toxicity.Z-LEHD-FMK (20 μM ; 6 h) protects normal human hepatocytes from TRAIL-induced apoptosis.Apoptosis Analysis Cell Line:SW480, H460, HCT116 and 293 cells Concentration:20 μM Incubation Time:Pretreated for 30 min Result:Protected HCT116 and 293 cells from TRAIL-induced apoptosis.Western Blot Analysis Cell Line:HCT116, SW480 cells Concentration:20 μM Incubation Time:2 h Result:Protected procaspase 3 from cleavage in HCT116 cells but not in SW480 cells, especially at the 16-h time point.
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In VivoZ-LEHD-FMK (0.8 μmol/kg; i.v. for 7 d) protects neurons, glia, myelin, axons, and intracellular organelles in spinal cord injury (SCI) rats.Animal Model:Male Wistar albino rats (250-350 g) with SCI Dosage:0.8 μmol/kg Administration:I.v. for 1 or 7 days Result:Decreased the mean apoptotic cell count at 24 hours and 7 days postinjury.
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Synonyms——
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PathwayApoptosis
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TargetCaspase
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RecptorCaspase | Apoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number210345-04-3
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Formula Weight690.72
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Molecular FormulaC32H43FN6O10
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (144.78 mM)
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SMILESCOC(=O)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(=O)OC)C(=O)CF
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ozoren N, et, al. The caspase 9 inhibitor Z-LEHD-FMK protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand. Cancer Res. 2000 Nov 15; 60(22): 6259-65.?
molnova catalog



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