Z-IETD-FMK ( Z-IE(OMe)TD(OMe)-FMK; Granzyme B Inhibitor III; Z-IETD-FMK )

Catalog No. M18230 CAS No. 210344-98-2

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Product Name

Z-IETD-FMK
Note

Research use only, not for human use.
Brief Description

Z-IETD-FMK is a selective caspase 8 inhibitor, which has cell permeable.
Description

MDK4982, also known as Z-IETD-FMK, is a potent, cell-permeable, irreversible inhibitor of caspase-8 and granzyme B., The Caspase-8 Inhibitor II controls the biological activity of Caspase-8. MDK4982 effectively inhibits influenza virus-induced apoptosis in HeLa cells. MDK4982 also inhibits granzyme B. MDK4982 has CAS#210344-98-2.
Synonyms

Z-IE(OMe)TD(OMe)-FMK; Granzyme B Inhibitor III; Z-IETD-FMK
Pathway

GPCR/G Protein
Target

Histamine Receptor
Recptor

Caspase-8
Research Area

Cancer
Indication

——

CAS Number

210344-98-2
Formula Weight

654.68
Molecular Formula

C30H43FN4O11
Purity

98%
Solubility

DMSO : 125 mg/mL 190.93 mM; H2O : < 0.1 mg/mL
SMILES

CC[C@H](C)[C@@H](C(=O)N[C@@H](CCC(=O)OC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1
Chemical Name

(5S,8S,11S,14S)-5-((S)-sec-butyl)-8-(2-carboxyethyl)-14-(2-fluoroacetyl)-11-((R)-1-hydroxyethyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oic acid

1. Tezel G, et al. Invest Ophthalmol Vis Sci. 1999 Oct;40(11):2660-7.

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