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Z-944
CAS No. 1199236-64-0
Z-944( Z944 )
Catalog No. M10714 CAS No. 1199236-64-0
Z-944 is a potent, highly selective and oral T-type calcium channel blocker with IC50 of 50-160 nM for human Cav3.1, Cav3.2, and Cav3.3 channels.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 60 | Get Quote |
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| 5MG | 102 | Get Quote |
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| 10MG | 170 | Get Quote |
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| 25MG | 345 | Get Quote |
|
| 50MG | 502 | Get Quote |
|
| 100MG | 718 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameZ-944
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NoteResearch use only, not for human use.
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Brief DescriptionZ-944 is a potent, highly selective and oral T-type calcium channel blocker with IC50 of 50-160 nM for human Cav3.1, Cav3.2, and Cav3.3 channels.
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DescriptionZ-944 is a potent, highly selective and oral T-type calcium channel blocker with IC50 of 50-160 nM for human Cav3.1, Cav3.2, and Cav3.3 channels; displays 70 times more potent for T-type blockade than for blockade of the N-type channel (IC50=11 uM); potently suppress seizure activity and attenuates burst firing of thalamic reticular nucleus neurons in the GAERS model of absence epilepsy; restores cortical synchrony and thalamocortical connectivity in a rat model of neuropathic pain.Pain Phase 1 Clinical.
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In Vitro——
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In Vivo——
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SynonymsZ944
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PathwayGPCR/G Protein
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TargetCalcium Channel
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RecptorCalcium Channel
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Research AreaNeurological Disease
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IndicationPain
Chemical Information
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CAS Number1199236-64-0
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Formula Weight383.89
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Molecular FormulaC19H27ClFN3O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (130.25 mM)
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SMILESO=C(NCC1CCN(CC(NC(C)(C)C)=O)CC1)C2=CC(F)=CC(Cl)=C2
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Chemical NameN-[[1-[2-(tert-butylamino)-2-oxoethyl]piperidin-4-yl]methyl]-3-chloro-5-fluorobenzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Tringham E, et al. Sci Transl Med. 2012 Feb 15;4(121):121ra19.
2. Casillas-Espinosa PM, et al. PLoS One. 2015 Aug 14;10(8):e0130012.
3. LeBlanc BW, et al. Pain. 2016 Jan;157(1):255-63.
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