Cart
sales@molnova.com
YS-49
CAS No. 132836-42-1
YS-49 ( —— )
Catalog No. M26515 CAS No. 132836-42-1
YS-49 is an activator of PI3K/Akt (a downstream target of RhoA).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 50 | Get Quote |
|
| 5MG | 83 | Get Quote |
|
| 10MG | 132 | Get Quote |
|
| 25MG | 260 | Get Quote |
|
| 50MG | 386 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameYS-49
-
NoteResearch use only, not for human use.
-
Brief DescriptionYS-49 is an activator of PI3K/Akt (a downstream target of RhoA).
-
DescriptionYS-49 is an activator of PI3K/Akt (a downstream target of RhoA).(In Vitro):In RAVSMC and RAW 264.7 cells, YS-49 (1-100?μM; 18 hours; ) concentration-dependently inhibits the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to lipopolysaccharide (LPS) plus INF-γ, with IC50 values of 22 μM and 30?μM, respectively.At the transcriptional level, YS-49 (10-100?μM; 18 hours; RAVSMC and RAW 264.7 cells) suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells .(In Vivo):In male Sprague Dawley rats,YS-49 (5?mg/kg; intraperitoneal injection; 8 hours) treatment significantly reduces serum NOx levels in LPS-treated rats, the NOx levels reduce from 86 μM to 34 μM.
-
Synonyms——
-
PathwayEndocrinology/Hormones
-
TargetRAAS
-
RecptorAPE1; Parasite; Topoisomerase I; Topoisomerase II
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number132836-42-1
-
Formula Weight386.3
-
Molecular FormulaC20H20BrNO2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESBr.Oc1cc2CCNC(Cc3cccc4ccccc34)c2cc1O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Pica Mattoccia L, et al. Effect of hycanthone administered in vivo upon the incorporation of radioactive precursors into macromolecules of Schistosoma mansoni. Mol Biochem Parasitol. 1983 Jun;8(2):99-107.
molnova catalog
related products
-
A 779(3TFA)
A 779(3TFA) is a potent antagonist of angiotensin-(1-7) receptor?.
-
Saralasin acetate(34...
Saralasin acetate is a Non-selective angiotensin II antagonist.
-
Quinapril hydrochlor...
Quinapril hydrochloride (Accupril) used in the treatment of hypertension and congestive heart failure.
