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YNT-185
CAS No. 1804978-81-1
YNT-185( —— )
Catalog No. M35102 CAS No. 1804978-81-1
YNT-185 is a nonpeptide, selective agonist of the orexin type-2 receptor (OX2R), with EC50 values of 0.028 μM for OX2R and 2.75 μM for OX1R.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 91 | Get Quote |
|
| 5MG | 140 | Get Quote |
|
| 10MG | 227 | Get Quote |
|
| 25MG | 440 | Get Quote |
|
| 50MG | 710 | Get Quote |
|
| 100MG | 945 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameYNT-185
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NoteResearch use only, not for human use.
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Brief DescriptionYNT-185 is a nonpeptide, selective agonist of the orexin type-2 receptor (OX2R), with EC50 values of 0.028 μM for OX2R and 2.75 μM for OX1R.
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DescriptionYNT-185 is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC50s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 ameliorates narcolepsy-cataplexy symptoms in mouse models.
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In Vitro——
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In VivoYNT-185 (20-40 mg/kg; i.p.) increases wakefulness in mice.YNT-185 (300 nmol; i.c.v.) significantly increases wake time for 3 hours in a dose-dependent manner, accompanied by a decrease in NREM sleep time, in wild-type mice but not in OXRDKO mice.Animal Model:Male wild-type C57BL/6J mice Dosage:20, 40 mg/kg Administration:I.p.Result:Wake time was also significantly increased.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOX Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1804978-81-1
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Formula Weight615.74
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Molecular FormulaC33H37N5O5S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (162.41 mM; Ultrasonic )
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SMILESS(NC1=CC(NCCNC(=O)C2=C(N(C)C)C=CC=C2)=CC=C1)(=O)(=O)C3=C(OC)C=CC(=C3)C4=CC(C(N(C)C)=O)=CC=C4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nagahara T, et al. Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists. J Med Chem. 2015;58(20):7931-7937.?
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