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YLT-11
CAS No. ——
YLT-11( PLK4 inhibitor YLT11 )
Catalog No. M17029 CAS No. ——
YLT-11 (PLK4 inhibitor YLT11) is a novel potent, selective, ATP-competitive PLK4 inhibitor with IC50 of 22 nM, Kd of 5.2 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameYLT-11
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NoteResearch use only, not for human use.
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Brief DescriptionYLT-11 (PLK4 inhibitor YLT11) is a novel potent, selective, ATP-competitive PLK4 inhibitor with IC50 of 22 nM, Kd of 5.2 nM.
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DescriptionYLT-11 (PLK4 inhibitor YLT11) is a novel potent, selective, ATP-competitive PLK4 inhibitor with IC50 of 22 nM, Kd of 5.2 nM; displays good selectivity over other PIMs and a panel of mitotic kinases, including JNK, TOPK, ERK, and so on; significantly decreases the viability of different subtypes of breast cancer cells with IC50 of 68-120 nM (MDA-MB-231, MDA-MB-468, BT549, and MCF-7 cells), also potently suppresses the DNA replication of cancer cells; significantly suppresses the tumor growth in human breast cancer xenograft models, orally active.
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In Vitro——
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In Vivo——
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SynonymsPLK4 inhibitor YLT11
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PathwayJAK/STAT Signaling
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TargetPim
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RecptorPim
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight412.497
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Molecular FormulaC24H24N6O
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Purity>98% (HPLC)
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Solubility——
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SMILESCC(NC1=NC=CC(C2=CC3=C(C=C2)C(/C=C/C4=CC=C(CN(C)C)C=C4)=NN3)=N1)=O
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Chemical Name(E)-N-(4-(3-(4-((dimethylamino)methyl)styryl)-1H-indazol-6-yl)pyrimidin-2-yl)acetamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lei Q, et al. Cell Death Dis. 2018 Oct 18;9(11):1066.
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