YL0919

Research use only, not for human use.

An orally active, dual 5-HT1A agonist and selective serotonin reuptake inhibitor with Ki of 0.19 nM and IC50 of 1.78 nM, respectively.

An orally active, dual 5-HT1A agonist and selective serotonin reuptake inhibitor with Ki of 0.19 nM and IC50 of 1.78 nM, respectively; shows no affinity for dopamine receptors and others 5-HT receptors; inhibits forskolin-stimulated cAMP formation and 5-HT uptake in both rat cortical synaptosomes and recombinant cells; significantly reverses the depressive-like behaviors in chronically stressed rats.

YL-0919;YL 0919

Endocrinology/Hormones

5-HT Receptor

5-HT; 5-HT1A

Neurological Disease

——

1339058-04-6

334.84

C18H23ClN2O2

>98% (HPLC)

DMSO: ≥ 30 mg/mL

O=C1C=CC=CN1CC2(O)CCN(CC3=CC=CC=C3)CC2.[H]Cl

2(1H)-Pyridinone, 1-[[4-hydroxy-1-(phenylmethyl)-4-piperidinyl]methyl]-, hydrochloride (1:1)

(-20℃)

With Ice Pack

≥ 2 years