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Home - Products - JAK/STAT Signaling - STAT - XZH-5

XZH-5

CAS No. 1360562-98-6

XZH-5 ( XZH5 )

Catalog No. M11481 CAS No. 1360562-98-6

XZH-5 is a small moelcule that inhibits constitutive and interleukin-6-induced STAT3 phosphorylation.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    XZH-5
  • Note
    Research use only, not for human use.
  • Brief Description
    XZH-5 is a small moelcule that inhibits constitutive and interleukin-6-induced STAT3 phosphorylation.
  • Description
    XZH-5 is a small moelcule that inhibits constitutive and interleukin-6-induced STAT3 phosphorylation, inhibits STAT3 DNA binding ability and downregulation of STAT3 downstream genes; inhibits downregulation of STAT3 downstream genes, such as Bcl-2, Bcl-xL, Cyclin D1 and Survivin, demonstrates blockade of STAT3 phosphorylation in human rhabdomyosarcoma cells with apoptosis and suppresses colony-forming ability and cell migration; blocks IL-6-induced STAT3 phosphorylation and nuclear translocation but not the stimulation of STAT1 phosphorylation by IFN-γ.
  • Synonyms
    XZH5
  • Pathway
    JAK/STAT Signaling
  • Target
    STAT
  • Recptor
    STAT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1360562-98-6
  • Formula Weight
    537.46
  • Molecular Formula
    C22H25F6N5O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(OC)[C@@H](N(NC(NC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)=O)C(CC(C)C)=O)CC2=CN(C)C=N2
  • Chemical Name
    methyl Na-(((3,5-bis(trifluoromethyl)phenyl)carbamoyl)-L-valyl)-Nt-methyl-L-histidinate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Liu Y, et al. Apoptosis. 2011 May;16(5):502-10.
2. Liu A, et al. Cancer Sci. 2011 Jul;102(7):1381-7.
3. Liu A, PLoS One. 2012;7(10):e46624.
4. Daka P, et al. Bioorg Med Chem. 2015 Mar 15;23(6):1348-55.
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