XL888

Research use only, not for human use.

XL888 is an ATP-competitive inhibitor of Hsp90 ( IC50: 24 nM). Heat shock protein 90 (Hsp90) is a chaperone that maintains the functionality of client proteins involved in cell proliferation, cell cycling, and apoptosis.

XL888 is an orally bioavailable, ATP-competitive, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp90 inhibitor XL888 specifically binds to Hsp90, inhibiting its chaperone function and promoting the proteasomal degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival; inhibition of tumor cell proliferation may result. Hsp90, a chaperone complex protein upregulated in a variety of tumor cell types, regulates the folding and degradation of many oncogenic signaling proteins, including Her-2 and Met.

XL888; XL-888; XL 888

Endocrinology/Hormones

5-HT Receptor

HSP90

Cancer

——

1149705-71-4

503.6

C29H37N5O3

98%

DMSO : ≥ 100 mg/mL; 198.55 mM

CC[C@@H](C)Nc1c(cc(C)c(c1)C(=O)NC1CC2CCC(C1)N2c1ncc(cc1)C(=O)C1CC1)C(=O)N

5-((R)-sec-butylamino)-N1-((1R,3s,5S)-8-(5-(cyclopropanecarbonyl)pyridin-2-yl)-8-azabicyclo[3.2.1]octan-3-yl)-2-methylterephthalamide

(-20℃)

With Ice Pack

≥ 2 years