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XEN-445

CAS No. 1515856-92-4

XEN-445( XEN445 | XEN 445 | XEN-445 )

Catalog No. M17330 CAS No. 1515856-92-4

XEN445, a potent and selective endothelial lipase(EL) inhibitor (IC50=0.237 uM), exhibitis good ADME and PK properties.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 50 In Stock
10MG 95 In Stock
25MG 178 In Stock
50MG 332 In Stock
100MG 514 In Stock
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Biological Information

  • Product Name
    XEN-445
  • Note
    Research use only, not for human use.
  • Brief Description
    XEN445, a potent and selective endothelial lipase(EL) inhibitor (IC50=0.237 uM), exhibitis good ADME and PK properties.
  • Description
    XEN445 is potent and selective endothelial lipase inhibitor, that showed good ADME and PK properties, and demonstrated in vivo efficacy in raising plasma HDLc concentrations in mice. Endothelial lipase (EL) activity has been implicated in HDL metabolism and in atherosclerotic plaque development; inhibitors are proposed to be efficacious in the treatment of dyslipidemia related cardiovascular disease.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    XEN445 | XEN 445 | XEN-445
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    endothelial lipase
  • Research Area
    Cardiovascular Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    1515856-92-4
  • Formula Weight
    366.33
  • Molecular Formula
    C18H17F3N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 40 mg/mL. 109.19 mM
  • SMILES
    c1(ccc(c(c1)C(=O)O)N1C[C@H](CC1)OCc1ncccc1)C(F)(F)F
  • Chemical Name
    (S)-2-(3-(pyridin-2-ylmethoxy)pyrrolidin-1-yl)-5-(trifluoromethyl)benzoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sun S, et al. Bioorg Med Chem. 2013, 21(24), 7724-7734.
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