XDM-CBP ( XDM CBP )

Catalog No. M13410 CAS No. 2138461-99-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

XDM-CBP
Note

Research use only, not for human use.
Brief Description

A highly potent and selective inhibitor of CBP/p300 bromodomain with Kd of 0.23/0.47 uM respectively.
Description

A highly potent and selective inhibitor of CBP/p300 bromodomain with Kd of 0.23/0.47 uM respectively, with high selectivity over all other BD families, including the BET family; exhibits antiproliferative effect on numerous cancer cell lines, in particular malignant melanoma, breast cancer, and leukemia (HL-60 and MCF-7 cells GI50=1.3 and 4.2 uM, respectively).
Synonyms

XDM CBP
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

Bromodomain
Research Area

——
Indication

——

CAS Number

2138461-99-9
Formula Weight

366.42
Molecular Formula

C21H22N2O4
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C1=C(CC)C(C(C)=O)=C(C)N1)NCC2=C3C(O)=CC=CC3=CC=C2O
Chemical Name

4-acetyl-N-((2,8-dihydroxynaphthalen-1-yl)methyl)-3-ethyl-5-methyl-1H-pyrrole-2-carboxamide

1. Hügle M, et al. Angew Chem Int Ed Engl. 2017 Aug 2. doi: 10.1002/anie.201705516.

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