WYE-687 ( WYE687; WYE 687; WYE-687 )

Catalog No. M17132 CAS No. 1062161-90-3

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Product Name

WYE-687
Note

Research use only, not for human use.
Brief Description

WYE-687 is an ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM; blocks mTORC1/pS6K(T389) and mTORC2/P-AKT(S473) but no effect observed on P-AKT(T308).
Description

WYE-687 is a potent and ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM.
Synonyms

WYE687; WYE 687; WYE-687
Pathway

Others
Target

Other Targets
Recptor

mTOR , PI3Kα , PI3Kγ , p38α , Src
Research Area

Cancer
Indication

——

CAS Number

1062161-90-3
Formula Weight

528.61
Molecular Formula

C28H32N8O3
Purity

98%
Solubility

——
SMILES

COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCN(CC4)CC5=CN=CC=C5)C(=N2)N6CCOCC6
Chemical Name

methyl (4-(4-morpholino-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenyl)carbamate

1. Yu K, et al, Cancer Res, 2009, 69(15), 6232-6240.

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