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WR-99210

CAS No. 30711-93-4

WR-99210 ( 6,6-Dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine; WR99210 hydrochloride(47326-86-3 free base) )

Catalog No. M24237 CAS No. 30711-93-4

WR-99210 is a potent inhibitor of?Plasmodium falciparum?dihydrofolate reductase (pfDHFR), which is a major malarial drug target.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 372 In Stock
25MG 619 In Stock
50MG 881 In Stock
100MG 1188 In Stock
500MG 2367 In Stock
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Biological Information

  • Product Name
    WR-99210
  • Note
    Research use only, not for human use.
  • Brief Description
    WR-99210 is a potent inhibitor of?Plasmodium falciparum?dihydrofolate reductase (pfDHFR), which is a major malarial drug target.
  • Description
    WR-99210 is a potent inhibitor of?Plasmodium falciparum?dihydrofolate reductase (pfDHFR), which is a major malarial drug target. It has subnanomolar potency for the wild type, double mutant and quadruple mutant dihydrofolate reductases.
  • Synonyms
    6,6-Dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine; WR99210 hydrochloride(47326-86-3 free base)
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    pfDHFR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    30711-93-4
  • Formula Weight
    431.1
  • Molecular Formula
    C14H19Cl4N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    NC1=NC(N)=NC(C)(C)N1OCCCOC2=CC(Cl)=C(Cl)C=C2Cl.[H]Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Canfield C J , Milhous W K , Ager A L , et al. PS-15: a potent, orally active antimalarial from a new class of folic acid antagonists.[J]. American Journal of Tropical Medicine & Hygiene, 1993, 49(1):121.
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