WH-4-023( WH-4-023 | WH4-023 | WH 4-023 | WH-4023 )

Catalog No. M16103 CAS No. 837422-57-8

COA

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HNMR

HPLC

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Product Name

WH-4-023
Note

Research use only, not for human use.
Brief Description

WH-4-023 is a potent and orally active Lck/Src inhibitor with IC50 of 2 nM and 6 nM in cell-free assays, respectively.
Description

WH-4-023 is a potent and orally active Lck/Src inhibitor with IC50 of 2 nM and 6 nM in cell-free assays, respectively.
In Vitro

——
In Vivo

——
Synonyms

WH-4-023 | WH4-023 | WH 4-023 | WH-4023
Pathway

Tyrosine Kinase
Target

Src
Recptor

Lck| Src
Research Area

Cancer
Indication

——

CAS Number

837422-57-8
Formula Weight

568.67
Molecular Formula

C32H36N6O4
Purity

>98% (HPLC)
Solubility

Ethanol: 6 mg/mL warmed (10.55 mM); DMSO: 12 mg/mL warmed (21.1 mM)
SMILES

O=C(OC1=C(C)C=CC=C1C)N(C2=CC=C(OC)C=C2OC)C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4)=NC=C3
Chemical Name

2,6-dimethylphenyl (2,4-dimethoxyphenyl)(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)carbamate

1.Martin MW, et al. J Med Chem. 2006 Aug 10;49(16): 4981-9

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