
WAY-600
CAS No. 1062159-35-6
WAY-600( WAY600 | WAY 600 | WAY600 )
Catalog No. M17131 CAS No. 1062159-35-6
WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 87 | Get Quote |
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5MG | 156 | Get Quote |
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10MG | 215 | Get Quote |
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25MG | 388 | Get Quote |
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50MG | 574 | Get Quote |
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100MG | 800 | Get Quote |
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500MG | 1647 | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameWAY-600
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NoteResearch use only, not for human use.
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Brief DescriptionWAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM.
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DescriptionWAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM.
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In VitroWAY-600 exhibits a concentration-dependent and time-dependent inhibition of f HepG2 and Huh-7 cells viability. Following WAY-600 (1-1000 nM) treatment, the number of HepG2 cell colonies is dramatically decreased. Meanwhile, BrdU incorporation in HepG2 cells is also inhibited with WAY-600 treatment. WAY-600 dose-dependently increases the activity of caspase-3 and caspase-9 in HepG2 cells. WAY-600 disrupts assemble of mTORC1 (mTOR-Raptor association) and mTORC2 (mTOR-Rictor association). Activation of mTORC1 (indicated by p-S6K1 and p-4E-BP1) and mTORC2 is almost blocked by WAY-600 (100 nM).
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In VivoAdministration of WAY-600 (10 mg/kg, daily) inhibits HepG2 tumor growth in nude mice. Daily HepG2 tumor growth of WAY-600-administrated mice is significantly lower than that of vehicle control mice. Importantly, the in vivo anti-cancer activity by WAY-600 is further potentiated with the co-administration of MEK-162 (2.5 mg/kg, p.o. daily).
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SynonymsWAY600 | WAY 600 | WAY600
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PathwayOthers
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TargetOther Targets
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RecptormTOR| PI3Kα| PI3Kγ| Src| VEGFR2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1062159-35-6
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Formula Weight494.59
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Molecular FormulaC28H30N8O
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Purity>98% (HPLC)
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SolubilityDMSO : 50 mg/mL 101.09 mM;H2O : < 0.1 mg/mL
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SMILESC(N1CCC(CC1)N1N=CC2=C1N=C(N=C2N1CCOCC1)C1=CC2=C(NC=C2)C=C1)C1=CC=CN=C1
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Chemical Name4-(6-(1H-indol-5-yl)-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)morpholine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yu K, et al, Cancer Res, 2009, 69(15), 6232-6240.
molnova catalog



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