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Voglibose

CAS No. 83480-29-9

Voglibose( AO-128, AO 128, Glustat, Voglibose, Voglib )

Catalog No. M19157 CAS No. 83480-29-9

Voglibose, an N-substituted derivative of valiolamine, exhibits excellent inhibitory activity against α-glucosidases and action against hyperglycemia and various disorders caused by hyperglycemia.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Voglibose
  • Note
    Research use only, not for human use.
  • Brief Description
    Voglibose, an N-substituted derivative of valiolamine, exhibits excellent inhibitory activity against α-glucosidases and action against hyperglycemia and various disorders caused by hyperglycemia.
  • Description
    Voglibose is an alpha-glucosidase inhibitor used for lowering post-prandial blood glucose levels in people with diabetes mellitus. Voglibose delays the absorption of glucose thereby reducing the risk of macrovascular complications. Voglibose was first launched in 1994, under the trade name BASEN, to improve postprandial hyperglycemia in diabetes mellitus. Postprandial hyperglycemia (PPHG) is primarily due to first phase insulin secretion. Alpha glucosidase inhibitors delay glucose absorption at the intestine level and thereby prevent sudden surge of glucose after a meal. There are three drugs which belong to this class, acarbose, miglitol and voglibose, of which voglibose is the newest. Voglibose has fewer side effects than both acarbose and miglitol. But acarbose has an edge over voglibose in terms of efficacy (FPG, PPHG, HBA1c).
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    AO-128, AO 128, Glustat, Voglibose, Voglib
  • Pathway
    Endocrinology/Hormones
  • Target
    RAAS
  • Recptor
    α-glucosidase
  • Research Area
    Metabolic Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    83480-29-9
  • Formula Weight
    267.28
  • Molecular Formula
    C10H21NO7
  • Purity
    >98% (HPLC)
  • Solubility
    H2O : ≥ 200 mg/mL; 748.28 mM
  • SMILES
    [C@]1([C@H]([C@@H]([C@H]([C@H](C1)NC(CO)CO)O)O)O)(O)CO
  • Chemical Name
    (1S,2S,3R,4S,5S)-5-(1,3-dihydroxypropan-2-ylamino)-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetraol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chen X, et al. Curr Med Chem, 2006, 13(1), 109-116.
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