Vesatolimod ( GS-9620; GS 9620; GS9620; Vesatolimod )

Catalog No. M17205 CAS No. 1228585-88-3

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Product Name

Vesatolimod
Note

Research use only, not for human use.
Brief Description

GS-9620 is an effective and specific orally active agonist of Toll-like receptor 7.
Description

Vesatolimod, also known as GS-9620, is a potent and oral agonist of Toll-like receptor-7 developed for finite treatment of chronic hepatitis B viral (HBV) infection, with the goal of inducing a liver-targeted antiviral effect without inducing the adverse effects associated with current systemic interferon-α (IFN-α) therapies. GS-9620 demonstrate interferon-stimulated gene induction without detectable serum interferon at low oral doses. GS-9620 can induce a sustained antiviral response in the woodchuck model of CHB.
Synonyms

GS-9620; GS 9620; GS9620; Vesatolimod
Pathway

Others
Target

Other Targets
Recptor

TLR7
Research Area

Inflammation/Immunology
Indication

——

CAS Number

1228585-88-3
Formula Weight

410.51
Molecular Formula

C22H30N6O2
Purity

98%
Solubility

DMSO : 4.8 mg/mL. 11.69 mM;
SMILES

CCCCOc1nc2c(c(n1)N)NC(=O)CN2Cc1cc(ccc1)CN1CCCC1
Chemical Name

4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one

1.Lanford RE. Gastroenterology. 2013 Feb 13. pii: S0016-5085(13)00169-8.

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