Verosudil( AR-12286 )

Catalog No. M11719 CAS No. 1414854-42-4

Verosudil (AR-12286) is a potent ROCK inhibitor (Ki=0.2 nM) that effectively lowers intraocular pressure (IOP) in animal models and human subjects.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Verosudil
Note

Research use only, not for human use.
Brief Description

Verosudil (AR-12286) is a potent ROCK inhibitor (Ki=0.2 nM) that effectively lowers intraocular pressure (IOP) in animal models and human subjects.
Description

Verosudil (AR-12286) is a potent ROCK inhibitor (Ki=0.2 nM) that effectively lowers intraocular pressure (IOP) in animal models and human subjects Other Indication Phase 2 Discontinued.
In Vitro

——
In Vivo

——
Synonyms

AR-12286
Pathway

Cell Cycle/DNA Damage
Target

ROCK
Recptor

ROCK
Research Area

Other Indications
Indication

Other Disease

Chemical Information

CAS Number

1414854-42-4
Formula Weight

327.402
Molecular Formula

C17H17N3O2S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 16.67 mg/mL (50.92 mM)
SMILES

CN(C)C(C1=CSC=C1)C(=O)NC2=CC3=C(C=C2)C(=O)NC=C3
Chemical Name

2-(dimethylamino)-N-(1-oxo- 1,2-dihydroisoquinolin-6-yl)-2-(thiophen-3-yl)acetamide

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Sturdivant JM, et al. Bioorg Med Chem Lett. 2016 May 15;26(10):2475-80. 2. Kopczynski C, et al. Br J Ophthalmol. 2013 May;97(5):567-72. 3. Williams RD, et al. Am J Ophthalmol. 2011 Nov;152(5):834-41.e1.

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