Verdinexor

Research use only, not for human use.

Verdinexor (KPT-335, KPT335) is an orally bioavailable, selective inhibitor of nuclear export (SINE), inhibits the function of nuclear export protein Exportin 1 (XPO1/CRM1) and the viability of Jurkat and canine DLBCL cells with IC50 of 8.7 nM and 13.3 nM, respectively.

Verdinexor (KPT-335, KPT335) is an orally bioavailable, selective inhibitor of nuclear export (SINE), inhibits the function of nuclear export protein Exportin 1 (XPO1/CRM1) and the viability of Jurkat and canine DLBCL cells with IC50 of 8.7 nM and 13.3 nM, respectively; induces apoptosis in CLBL1 cells and primary canine DLBCL cells; reduces influenza a virus replication in vitro and in vivo; also inhibits XPO1-mediated transport and reduces RSV replication in vitro, shows effectivity against RSV A and B strains and reduces viral replication following prophylactic or therapeutic administration.Influenza Phase 1 Clinical.

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KPT-335 | KPT335

Membrane Transporter/Ion Channel

Exportin-1

Exportin-1

Infection

Influenza

1392136-43-4

441.337

C19H13F6N5O

>98% (HPLC)

DMSO: 82 mg/mL (185.4 mM); Ethanol: 9 mg/mL (20.3 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )

O=C(NNC1=NC=CC=C1)/C=C\N2N=C(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)N=C2

(Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N-(pyridin-2-ylmethyl)acrylamide

(-20℃)

With Ice Pack

≥ 2 years