Vanillylacetone( Zingerone | AI3-31837 | Gingerone )

Catalog No. M17890 CAS No. 122-48-5

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Product Name

Vanillylacetone
Note

Research use only, not for human use.
Brief Description

Vanillylacetone, which is used as a flavor additive in spice oils and in perfumery to introduce spicy aromas, is similar in chemical structure to flavor chemicals such as vanillin and eugenol.
Description

Zingerone is absent in fresh ginger but cooking or heating transforms gingerol to zingerone. The compound has potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrheal, and antispasmodic properties. It behaves as appetite stimulant, anxiolytic, antithrombotic, radiation protective, and antimicrobial. Also, it inhibits the reactive nitrogen species important in causing Alzheimer's disease and many other disorders.
In Vitro

Zingerone is a nontoxic methoxyphenol with potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic properties.Zingerone (0-2 mM) decreases neruoblastoma cell survival.Zingerone (0-2 mM) reduces cyclin D1 expression, increases cleavage of caspase-3 and PARP-1 in BE(2)-M17 cells.
In Vivo

Zingerone (50, 100 ?mg/kg, p.o. daily for 21?days) protects against alloxan-induced diabetes via alleviation of oxidative stress and inflammation in rat.Zingerone (10 mg/kg, i.p.) inhibits tumor progression through mitotic arrest, failure of cell division, and stimulation of apoptosis.
Synonyms

Zingerone | AI3-31837 | Gingerone
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Others-Field
Indication

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1. Chen JC, et al. J Agric Food Chem, 2007, 55(21), 8390-8397.

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