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Valrubicin

CAS No. 56124-62-0

Valrubicin( AD-32 )

Catalog No. M21670 CAS No. 56124-62-0

Valrubicin (AD 32) inhibits TPA- and PDBu-induced PKC activation (IC50s: 0.85 and 1.25 μM) and has antitumor and anti-inflammatory activity.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Valrubicin
  • Note
    Research use only, not for human use.
  • Brief Description
    Valrubicin (AD 32) inhibits TPA- and PDBu-induced PKC activation (IC50s: 0.85 and 1.25 μM) and has antitumor and anti-inflammatory activity.
  • Description
    Valrubicin (AD 32) inhibits TPA- and PDBu-induced PKC activation (IC50s: 0.85 and 1.25 μM) and has antitumor and anti-inflammatory activity.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    AD-32
  • Pathway
    Angiogenesis
  • Target
    PKC
  • Recptor
    PKC
  • Research Area
    Cancer
  • Indication
    Bladder cancer

Chemical Information

  • CAS Number
    56124-62-0
  • Formula Weight
    723.64
  • Molecular Formula
    C34H32F3NO13
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥125 mg/mL (172.74 mM);Water: Insoluble
  • SMILES
    CCCCC(OCC([C@]1(O)CC2=C(C(O)=C3C(C4=C(C(C3=C2O)=O)C=CC=C4OC)=O)[C@@H](O[C@]5C[C@](NC(C(F)(F)F)=O)[C@](O)[C@](C)O5)C1)=O)=O
  • Chemical Name
    2-oxo-2-((2S4S)-2512-trihydroxy-4-(((2S4S5S6S)-5-hydroxy-6-methyl-4-(222-trifluoroacetamido)tetrahydro-2H-pyran-2-yl)oxy)-7-methoxy-611-dioxo-1234611-hexahydrotetracen-2-yl)ethyl pentanoate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Chuang LF et al. Activation of human leukemia protein kinase C by tumor promoters and its inhibition by N-trifluoroacetyladriamycin-14-valerate (AD 32). Biochem Pharmacol. 1992 Feb 18;43(4):865-72.
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