VZ185 ( VZ-185;VZ 185 )

Catalog No. M13645 CAS No. 2306193-61-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

VZ185
Note

Research use only, not for human use.
Brief Description

VZ185 (VZ-185) is a potent, fast and selective, VHL-based dual degrader probe (PROTAC) of BRD9 and BRD7 with DC50 of 1.8 and 4.5 nM, respectively.
Description

VZ185 (VZ-185) is a potent, fast and selective, VHL-based dual degrader probe (PROTAC) of BRD9 and BRD7 with DC50 of 1.8 and 4.5 nM, respectively; induces strong and rapid degradation of of BRD9, BRD7 in a time- and dose-dependent manner after treatment of RI-1 cells, also shows a DC50 between 2-8 nM for BRD9 in a panel of other human cancer cell lines (EOL-1, A-204).
Synonyms

VZ-185;VZ 185
Pathway

PROTACs
Target

PROTAC
Recptor

PROTAC
Research Area

——
Indication

——

CAS Number

2306193-61-1
Formula Weight

995.23
Molecular Formula

C53H67FN8O8S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C([C@H]1N(C([C@@H](NC(C2(F)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3OCCCCCN5CCN(CC6=C(OC)C=C(C(C7=CC=NC=C87)=CN(C)C8=O)C=C6OC)CC5
Chemical Name

(2S,4R)-N-(2-((5-(4-(2,6-dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)benzyl)piperazin-1-yl)pentyl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide

1. Zoppi V, et al. J Med Chem. 2018 Dec 12. doi: 10.1021/acs.jmedchem.8b01413.

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