Cart
sales@molnova.com
VU591
CAS No. 1222810-74-3
VU591( —— )
Catalog No. M22472 CAS No. 1222810-74-3
VU591 is the first reported selective, small-molecule ROMK inhibitor(IC50 of 0.24 μM).?It inhibits potassium transport in isolated perfused rat collecting duct tubules with no effect on sodium transport.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 65 | In Stock |
|
| 10MG | 110 | In Stock |
|
| 25MG | 215 | In Stock |
|
| 50MG | 385 | In Stock |
|
| 100MG | 575 | In Stock |
|
| 500MG | 1233 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameVU591
-
NoteResearch use only, not for human use.
-
Brief DescriptionVU591 is the first reported selective, small-molecule ROMK inhibitor(IC50 of 0.24 μM).?It inhibits potassium transport in isolated perfused rat collecting duct tubules with no effect on sodium transport.
-
DescriptionVU591 is the first reported selective, small-molecule ROMK inhibitor(IC50 of 0.24 μM).?It inhibits potassium transport in isolated perfused rat collecting duct tubules with no effect on sodium transport.
-
In VitroVU591 is a selective ROMK inhibitor and a ROMK channel pore blocker. VU591 can bind serum protein and has high metabolic stability.
-
In VivoVU591 (i.c.v.; 1.842 μg) significantly decreases the immobile time in TST. Animal Model:Male ICR miceDosage:1.842 μg Administration:i.c.v.; 1.842 μg; Result:Showed antidepressive effect in the tail suspension test (TST).
-
Synonyms——
-
PathwayCell Cycle/DNA Damage
-
TargetPotassium Channel
-
RecptorKir1.1|ROMK
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1222810-74-3
-
Formula Weight368.3
-
Molecular FormulaC16H12N6O5
-
Purity>98% (HPLC)
-
SolubilityDMSO:60 mg/mL (162.91 mM; Need ultrasonic)
-
SMILES[O-][N+](=O)c1ccc2nc(COCc3nc4ccc(cc4[nH]3)[N+]([O-])=O)[nH]c2c1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Bhave G, et al. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol. 2011 Jan;79(1):42-50.
molnova catalog
related products
-
KCC2 blocker 1
(+)-KCC2 blocker 1 is a selective blocker of KCC2 (IC50 = 0.4 μM).
-
MonoMethyl auristati...
Monomethyl auristatin F, an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin.
-
VCMMAE
VcMMAE is a drug-linker conjugate for ADC with potent antitumor activity.
