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VU533
CAS No. 923417-09-8
VU533( —— )
Catalog No. M36992 CAS No. 923417-09-8
VU533 (Nape-Pld activator) is a NAPE-PLD activator with an EC50 value of 0.30 μM.VU533 enhances NAPE-PLD activity and increases macrophage cytosolic burial.VU533 may be used in diseases associated with cardiometabolism.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 65 | In Stock |
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| 5MG | 93 | In Stock |
|
| 10MG | 155 | In Stock |
|
| 25MG | 302 | In Stock |
|
| 50MG | 495 | In Stock |
|
| 100MG | 691 | In Stock |
|
| 500MG | 1395 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameVU533
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NoteResearch use only, not for human use.
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Brief DescriptionVU533 (Nape-Pld activator) is a NAPE-PLD activator with an EC50 value of 0.30 μM.VU533 enhances NAPE-PLD activity and increases macrophage cytosolic burial.VU533 may be used in diseases associated with cardiometabolism.
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DescriptionAPE-PLD (VU533) activator is a potent NAPE-PLD activator with an EC50 value of 0.30 μM. NAPE-PLD activator (VU533) can enhance NAPE-PLD activity and increase efferocytosis by macrophages. NAPE-PLD activator (VU533) can be used for cardiometabolic diseases research.
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In VitroCell Cytotoxicity Assay Cell Line:RAW264.7, HepG2 Concentration:0.1-30 μM Incubation Time:24 h Result:Showed no cytotoxicity when tested at 30 μM in either RAW264.7 or HepG2 cells.Cell Autophagy Assay Cell Line:BMDM Concentration:10 μM Incubation Time:6 h Result:Enhanced efferocytosis compared to vehicle treated BMDM at 10μM.
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetPhospholipase
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RecptorPhospholipase
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Research Area——
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Indication——
Chemical Information
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CAS Number923417-09-8
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Formula Weight447.55
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Molecular FormulaC21H22FN3O3S2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (279.30 mM; Ultrasonic (<60°C)
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SMILESCC1=CC=C(C)C2=C1SC(NC(=O)C1CCN(CC1)S(=O)(=O)C1=CC=C(F)C=C1)=N2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Sephin1
Sephin1 is reportedly a selective inhibitor of GADD34 (PPP1R15A), which is a stress-induced regulatory subunit of protein phosphatase 1 complex that dephosphorylates eIF2α
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Isepamicin sulfate
Isepamicin Sulphate, an aminoglycoside antibacterial with good activity against strains producing type I 6-acetyltransferase, inhibits bacterial protein synthesis by targeting the bacterial 30S ribosomal subunit.
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Melittin TFA(20449-7...
Melittin TFA is a small protein containing 26 amino acid residues, is the principal toxic component of bee venom. Melittin is a PLA2 activator, stimulates the activity of the low molecular weight PLA2, while it does not the increase activity of the high molecular weight PLA2.Melittin, an immunologically related PLA2 stimulating peptide from bee venom, increases the activity of the high molecular weight enzyme.
