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VT104

CAS No. 2417718-25-1

VT104( —— )

Catalog No. M36039 CAS No. 2417718-25-1

VT104 is a potent and orally active YAP/TAZ inhibitor for cancer research. VT104 blocks palmitoylation of endogenous TEAD1 and TEAD3 proteins.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 242 In Stock
10MG 394 In Stock
25MG 619 In Stock
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Biological Information

  • Product Name
    VT104
  • Note
    Research use only, not for human use.
  • Brief Description
    VT104 is a potent and orally active YAP/TAZ inhibitor for cancer research. VT104 blocks palmitoylation of endogenous TEAD1 and TEAD3 proteins.
  • Description
    VT104 is a potent and orally active YAP/TAZ inhibitor. VT104 prevents palmitoylation of endogenous TEAD1 and TEAD3 proteins. VT104 can be used in research of cancer.
  • In Vitro
    ——
  • In Vivo
    Animal Model:NCI-H226-tumor bearing mice Dosage:0.3, 1, and 3 mg/kg Administration:Oral administration Result:Blocked NCI-H226 tumor growth in mice in dose-dependent manner.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    YAP
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2417718-25-1
  • Formula Weight
    420.43
  • Molecular Formula
    C25H19F3N2O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (237.85 mM; Ultrasonic )
  • SMILES
    C[C@H](NC(=O)c1ccc2c(cccc2c1)-c1ccc(cc1)C(F)(F)F)c1ccccn1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tang TT, et, al. Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. Mol Cancer Ther. 2021 Jun;20(6):986-998.?
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