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VT103

CAS No. 2290608-13-6

VT103( —— )

Catalog No. M35616 CAS No. 2290608-13-6

VT103 is an orally active and selective inhibitor of TEAD1 protein palmitoylation and is an analog of VT101.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    VT103
  • Note
    Research use only, not for human use.
  • Brief Description
    VT103 is an orally active and selective inhibitor of TEAD1 protein palmitoylation and is an analog of VT101.
  • Description
    VT103, an analog of VT101, is an orally active and selective TEAD1 protein palmitoylation inhibitor. VT103 inhibits YAP/TAZ-TEAD promoted gene transcription, blocks TEAD auto-palmitoylation, and disrupts interaction between YAP/TAZ and TEAD. VT103 can be used for the research of cancer.
  • In Vitro
    VT103 (HEK293T cells; 3 μM) appeares to be TEAD1-selective, as it does not block palmitoylation of TEAD2, TEAD3, or TEAD4. VT103 (NF2-deficient NCI-H226 cells; 3 mmol/L; 4 or 24 hours) selectively disrupts YAP–TEAD1 interaction.VT103 results in the disappearance of palmitoylated TEAD1 with a concomitant increase in unpalmitoylated TEAD1.VT103 shows an IC50 of 1.02 nM in YAP reporter assay.
  • In Vivo
    VT103 (0.3~10 mg/kg; p.o. once per day) blocks tumor growth even at 0.3 mg/kg.Animal Model:NCI-H226-tumor bearing miceDosage:0.3~10 mg/kg Administration:P.o. once per day Result:Blocked tumor growth even at 0.3 mg/kg.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    YAP
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2290608-13-6
  • Formula Weight
    410.41
  • Molecular Formula
    C18H17F3N4O2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (121.83 mM; Ultrasonic )
  • SMILES
    CNS(=O)(=O)c1ccc(Nc2ccc(cc2)C(F)(F)F)c(c1)-c1cn(C)cn1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tang TT, et al. Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. Mol Cancer Ther. 2021;20(6):986-998.?
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