VRK-IN-1

CAS No. 2378855-09-3

VRK-IN-1( —— )

Catalog No. M34797 CAS No. 2378855-09-3

VRK-IN-1 is a potent and selective inhibitor of [cowpox-associated kinase 1 (VRK1)], suitable for researching neurological disorders.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    VRK-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    VRK-IN-1 is a potent and selective inhibitor of [cowpox-associated kinase 1 (VRK1)], suitable for researching neurological disorders.
  • Description
    VRK-IN-1 is a potent and selective inhibitor of vaccinia-related kinases 1 (VRK1), with an IC50 of 150 nM. VRK1 is human Ser/Thr protein kinases associated with increased cell division and neurological disorders.
  • In Vitro
    VRK-IN-1 binds to VRK1-FL by enthalpy-driven, with a Kd of 190 nM.VRK-IN-1 (0.4-25 μM; 24 h) slightly decreases the viability of human HeLa cells at the concentration of 3.2 μM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2378855-09-3
  • Formula Weight
    349.28
  • Molecular Formula
    C18H11F4NO2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (286.30 mM; Ultrasonic )
  • SMILES
    Cc1ncc(cc1-c1cc(F)c(O)c(F)c1)-c1cc(F)c(O)c(F)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Serafim RAM, et, al. Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2. ACS Med Chem Lett. 2019 Aug 19;10(9):1266-1271.?
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