VRK-IN-1( —— )

Catalog No. M34797 CAS No. 2378855-09-3

VRK-IN-1 is a potent and selective inhibitor of [cowpox-associated kinase 1 (VRK1)], suitable for researching neurological disorders.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

VRK-IN-1
Note

Research use only, not for human use.
Brief Description

VRK-IN-1 is a potent and selective inhibitor of [cowpox-associated kinase 1 (VRK1)], suitable for researching neurological disorders.
Description

VRK-IN-1 is a potent and selective inhibitor of vaccinia-related kinases 1 (VRK1), with an IC50 of 150 nM. VRK1 is human Ser/Thr protein kinases associated with increased cell division and neurological disorders.
In Vitro

VRK-IN-1 binds to VRK1-FL by enthalpy-driven, with a Kd of 190 nM.VRK-IN-1 (0.4-25 μM; 24 h) slightly decreases the viability of human HeLa cells at the concentration of 3.2 μM.
In Vivo

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Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

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Chemical Information

CAS Number

2378855-09-3
Formula Weight

349.28
Molecular Formula

C18H11F4NO2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (286.30 mM; Ultrasonic )
SMILES

Cc1ncc(cc1-c1cc(F)c(O)c(F)c1)-c1cc(F)c(O)c(F)c1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Serafim RAM, et, al. Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2. ACS Med Chem Lett. 2019 Aug 19;10(9):1266-1271.?

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