
VRK-IN-1
CAS No. 2378855-09-3
VRK-IN-1( —— )
Catalog No. M34797 CAS No. 2378855-09-3
VRK-IN-1 is a potent and selective inhibitor of [cowpox-associated kinase 1 (VRK1)], suitable for researching neurological disorders.
Purity : >98% (HPLC)






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Biological Information
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Product NameVRK-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionVRK-IN-1 is a potent and selective inhibitor of [cowpox-associated kinase 1 (VRK1)], suitable for researching neurological disorders.
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DescriptionVRK-IN-1 is a potent and selective inhibitor of vaccinia-related kinases 1 (VRK1), with an IC50 of 150 nM. VRK1 is human Ser/Thr protein kinases associated with increased cell division and neurological disorders.
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In VitroVRK-IN-1 binds to VRK1-FL by enthalpy-driven, with a Kd of 190 nM.VRK-IN-1 (0.4-25 μM; 24 h) slightly decreases the viability of human HeLa cells at the concentration of 3.2 μM.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number2378855-09-3
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Formula Weight349.28
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Molecular FormulaC18H11F4NO2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (286.30 mM; Ultrasonic )
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SMILESCc1ncc(cc1-c1cc(F)c(O)c(F)c1)-c1cc(F)c(O)c(F)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Serafim RAM, et, al. Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2. ACS Med Chem Lett. 2019 Aug 19;10(9):1266-1271.?
molnova catalog



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