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VPC-70063

CAS No. 13571-44-3

VPC-70063( Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)- )

Catalog No. M28492 CAS No. 13571-44-3

VPC-70063 is an inhibitor of c-Myc-MAX. VPC-70063 exhibits Myc-Max transcriptional activity inhibition of 106% with an IC50 of 8.9 μM and Myc-Max/UBE2C downstream pathway inhibition of 94%. VPC-70063 can be used for studies about anticancer.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    VPC-70063
  • Note
    Research use only, not for human use.
  • Brief Description
    VPC-70063 is an inhibitor of c-Myc-MAX. VPC-70063 exhibits Myc-Max transcriptional activity inhibition of 106% with an IC50 of 8.9 μM and Myc-Max/UBE2C downstream pathway inhibition of 94%. VPC-70063 can be used for studies about anticancer.
  • Description
    VPC-70063 is an inhibitor of c-Myc-MAX. VPC-70063 exhibits Myc-Max transcriptional activity inhibition of 106% with an IC50 of 8.9 μM and Myc-Max/UBE2C downstream pathway inhibition of 94%. VPC-70063 can be used for studies about anticancer.(In Vitro):VPC-70063 (6.25, 12.5, and 25 μM) causes apoptosis of LNCaP cells as indicated by cleavage of PARP. VPC-70063 (0-500 μM) disrupts the interaction of Myc-Max with DNA in a dose-dependent manner.
  • In Vitro
    VPC-70063 (25 μM; 96 h) shows Myc-Max transcriptional activity inhibition of 106% and Myc-Max/UBE2C downstream pathway inhibition of 94%.VPC-70063 (6.25-25 μM, 48 h) causes apoptosis of LNCaP cells as indicated by cleavage of PARP.VPC-70063 (0-500 μM; 0-600 s) disrupts the interaction of Myc-Max with DNA in a dose dependent manner.Western Blot Analysis Cell Line:LNCaP cells Concentration:6.25 μM, 12.5 μM and 25 μM Incubation Time:48 h Result:Induced PARP cleavage.
  • In Vivo
    ——
  • Synonyms
    Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    P2X3
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    13571-44-3
  • Formula Weight
    378.33
  • Molecular Formula
    C16H12F6N2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    FC(F)(F)C1=CC(=CC(=C1)C(F)(F)F)NC(=S)NCC=2C=CC=CC2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

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