
VPC-18005
CAS No. 2242480-48-2
VPC-18005( —— )
Catalog No. M28514 CAS No. 2242480-48-2
VPC-18005 is a luciferase inhibitor. VPC-18005 inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain thereby disrupting the ERG binding to DNA.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 222 | Get Quote |
![]() ![]() |
10MG | 357 | Get Quote |
![]() ![]() |
25MG | 597 | Get Quote |
![]() ![]() |
50MG | 851 | Get Quote |
![]() ![]() |
100MG | 1152 | Get Quote |
![]() ![]() |
500MG | 2313 | Get Quote |
![]() ![]() |
1G | Get Quote | Get Quote |
![]() ![]() |
Biological Information
-
Product NameVPC-18005
-
NoteResearch use only, not for human use.
-
Brief DescriptionVPC-18005 is a luciferase inhibitor. VPC-18005 inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain thereby disrupting the ERG binding to DNA.
-
DescriptionVPC-18005 is a luciferase inhibitor. VPC-18005 inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain thereby disrupting the ERG binding to DNA.(In Vitro):VPC-18005 (1 and 10 μM) produced a 20–30% decrease in the dissemination of cancer cells in zebrafsh. VPC-18005 (5 μM) inhibits pETS-luc reporter activity with IC50s of 3 and 6 μM in PNT1B-ERG and VCaP cells, respectively. VPC-18005 antagonizes the metastatic potential of ERG-expressing prostate cells and suppresses ERG reporter activity without exhibiting overt cytotoxicity. VPC-18005 inhibits migration and invasion of ERG-overexpressing cells in vitro.
-
In VitroVPC-18005 is found to inhibit pETS-luc reporter activity in PNT1B-ERG and VCaP cells with IC50 values of 3 and 6 μM, respectively.VPC-18005 could suppress ERG reporter activity without exhibiting overt cytotoxicity.VPC-18005 inhibits migration and invasion of ERG-overexpressing cells in vitro.VPC-18005 can antagonize the metastatic potential of ERG-expressing prostate cells.The exposure of larvae to 1 or 10 μM of VPC-18005 produced a 20–30% decrease in the dissemination of cancer cells in zebrafsh. Cell Viability AssayCell Line:PNT1B-Mock cells and PNT1B-ERG cells.Concentration:5 μM.Incubation Time:24 h.Result:Inhibited migration and invasion of prostate cell lines in vitro.
-
In Vivo——
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
Recptor——
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2242480-48-2
-
Formula Weight319.38
-
Molecular FormulaC15H17N3O3S
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 62.5 mg/mL (195.69 mM)
-
SMILESN(/N=C\C1=CC=C(C(C)C)C=C1)=C\2/SC(CC(O)=O)C(=O)N2
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
molnova catalog



related products
-
Bunaftide
Bunaftide (Bunaphtid) has antiarrhythmic effects and inhibits aconitine-induced ventricular tachycardia.
-
N4-Benzoyl-2′-deoxyc...
N4-Benzoyl-2′-deoxycytidine is a chemical compound.
-
Allura Red AC
Allura Red AC is a very important food azo dye used in the food, pharmaceutical, paper, cosmetic and textile industries.Allura Red AC promotes susceptibility to experimental colitis via mouse intestinal serotonin.