VK-28

Research use only, not for human use.

VK-28 is a brain permeable iron chelator with neuroprotection. VK-28 inhibits basal as well as iron-induced mitochondrial lipid peroxidation.

VK-28 is a brain permeable iron chelator with neuroprotection. VK-28 inhibits basal as well as iron-induced mitochondrial lipid peroxidation.(In Vitro):VK-28 inhibited both basal and Fe/ascorbate induced mitochondrial membrane lipid peroxidation, with an IC50 of 12.7 microM comparable to that of the prototype iron chelator, desferal, which does not cross the blood brain barrier.(In Vivo):VK-28(1 microg; i.c.v.) was able to completely protect against ICV 6-OHDA (250 microg) induced striatal dopaminergic lesion, as measured by dopamine (DA), dihydroxyphenylacetic acid (DOPAC) and homovanilic acid (HVA) levels. VK-28 (1 and 5 mg/kg; i.p.) daily for 10 and 7 days, respectively, demonstrated significant neuroprotection against ICV 6-OHDA at the higher dose, with 68% protection against loss of dopamine at 5mg/kg dosage of VK-28.

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Others

Other Targets

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312611-92-0

287.4

C16H21N3O2

>98% (HPLC)

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OCCN1CCN(CC2=CC=C(O)C3=NC=CC=C23)CC1

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(-20℃)

With Ice Pack

≥ 2 years