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VK-28
CAS No. 312611-92-0
VK-28 ( —— )
Catalog No. M28982 CAS No. 312611-92-0
VK-28 is a brain permeable iron chelator with neuroprotection. VK-28 inhibits basal as well as iron-induced mitochondrial lipid peroxidation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 393 | Get Quote |
|
| 10MG | 581 | Get Quote |
|
| 25MG | 888 | Get Quote |
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| 50MG | 1242 | Get Quote |
|
| 100MG | 1674 | Get Quote |
|
| 500MG | 3348 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameVK-28
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NoteResearch use only, not for human use.
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Brief DescriptionVK-28 is a brain permeable iron chelator with neuroprotection. VK-28 inhibits basal as well as iron-induced mitochondrial lipid peroxidation.
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DescriptionVK-28 is a brain permeable iron chelator with neuroprotection. VK-28 inhibits basal as well as iron-induced mitochondrial lipid peroxidation.(In Vitro):VK-28 inhibited both basal and Fe/ascorbate induced mitochondrial membrane lipid peroxidation, with an IC50 of 12.7 microM comparable to that of the prototype iron chelator, desferal, which does not cross the blood brain barrier.(In Vivo):VK-28(1 microg; i.c.v.) was able to completely protect against ICV 6-OHDA (250 microg) induced striatal dopaminergic lesion, as measured by dopamine (DA), dihydroxyphenylacetic acid (DOPAC) and homovanilic acid (HVA) levels. VK-28 (1 and 5 mg/kg; i.p.) daily for 10 and 7 days, respectively, demonstrated significant neuroprotection against ICV 6-OHDA at the higher dose, with 68% protection against loss of dopamine at 5mg/kg dosage of VK-28.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number312611-92-0
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Formula Weight287.4
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Molecular FormulaC16H21N3O2
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Purity>98% (HPLC)
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Solubility——
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SMILESOCCN1CCN(CC2=CC=C(O)C3=NC=CC=C23)CC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Fedosejevs ET, Feil R, Lunn JE, Plaxton WC. The signal metabolite trehalose-6-phosphate inhibits the sucrolytic activity of sucrose synthase from developing castor beans. FEBS Lett. 2018 Aug;592(15):2525-2532.
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