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VH032-PEG4-NH2

CAS No. 2010159-57-4

VH032-PEG4-NH2( VH032-PEG4-NH2 | VHL Ligand-Linker Conjugates 4 | E3 ligase Ligand-Linker Conjugates 7 Free Base )

Catalog No. M26674 CAS No. 2010159-57-4

(S,R,S)-AHPC-PEG4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    VH032-PEG4-NH2
  • Note
    Research use only, not for human use.
  • Brief Description
    (S,R,S)-AHPC-PEG4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.
  • Description
    (S,R,S)-AHPC-PEG4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.
  • In Vitro
    E3 ligase Ligand-Linker Conjugates 7 Free Base, extracted from patent US20170008904A1, can be used in the synthesis of compound A1895 in example 3.
  • In Vivo
    ——
  • Synonyms
    VH032-PEG4-NH2 | VHL Ligand-Linker Conjugates 4 | E3 ligase Ligand-Linker Conjugates 7 Free Base
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    AhR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2010159-57-4
  • Formula Weight
    663.83
  • Molecular Formula
    C32H49N5O8S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 170 mg/mL (256.09 mM)
  • SMILES
    O=C(N[C@@H](C(C)(C)C)C(N(C[C@H](O)C1)[C@@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)=O)COCCOCCOCCOCCN
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Misaki K, et al. Aryl hydrocarbon receptor ligand activity of polycyclic aromatic ketones and polycyclic aromatic quinones. Environ Toxicol Chem. 2007 Jul;26(7):1370-9.
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