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Ulocuplumab
CAS No. 1375830-34-4
Ulocuplumab( —— )
Catalog No. M36724 CAS No. 1375830-34-4
Ulocuplumab (BMS-936564) is a fully human anti-CXCR4 IgG4 antibody.Ulocplumab exhibits antitumor activity in acute myeloid leukemia (AML), non-Hodgkin's lymphoma (NHL), and multiple myeloma transplantation models.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 375 | Get Quote |
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| 5MG | 673 | Get Quote |
|
| 10MG | 938 | Get Quote |
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| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameUlocuplumab
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NoteResearch use only, not for human use.
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Brief DescriptionUlocuplumab (BMS-936564) is a fully human anti-CXCR4 IgG4 antibody.Ulocplumab exhibits antitumor activity in acute myeloid leukemia (AML), non-Hodgkin's lymphoma (NHL), and multiple myeloma transplantation models.
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DescriptionUlocuplumab (Anti-Human CXCR4 Recombinant Antibody/BMS-936564/MDX1338) is a fully human IgG4 anti-CXCR4 antibody. Ulocuplumab induces apoptosis and inhibits CXCL12 mediated CXCR4 activation-migration of chronic lymphocytic leukemia (CLL). Ulocuplumab exhibits antitumor activity in established tumors including acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL), and multiple myeloma xenograft models.
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In VitroApoptosis Analysis Cell Line:Ramos cells and primary leukemia cells (from CLL patients)Concentration:0-100 μM Incubation Time:48 hours Result:Induced apoptosis in Ramos cells with an IC50 value of 1.9 nM and showed pro-apoptotic with an IC50 value of 12.43 nM in primary leukemia cells from CLL patients.
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In VivoAnimal Model:Severe combined immunodeficient (SCID) mice of AML model (MOLP-8 cells) Dosage:3-30 mg/kg Administration:Intraperitoneal injection; every 3-4 days for 5 doses; last for 65 days Result:Significantly delayed mean tumor growth by 66% and 56% when compared with isotype control on day 25.
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Synonyms——
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PathwayAutophagy
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TargetCXCR
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RecptorCXCR | Apoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number1375830-34-4
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Formula Weight146.2 (kDa)
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Molecular Formula——
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kashyap MK, et al. Ulocuplumab (BMS-936564 / MDX1338): a fully human anti-CXCR4 antibody induces cell death in chronic lymphocytic leukemia mediated through a reactive oxygen species-dependent pathway. Oncotarget. 2016 Jan 19;7(3):2809-22. ?
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