Cart
sales@molnova.com
UV0155041
CAS No. 1093757-42-6
UV0155041( UV0155041 | UV-0155041 | UV 0155041 )
Catalog No. M17141 CAS No. 1093757-42-6
UV0155041 is an effective and positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50: 798/693 nM, at human/rat).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 51 | In Stock |
|
| 5MG | 80 | In Stock |
|
| 10MG | 115 | In Stock |
|
| 25MG | 222 | In Stock |
|
| 50MG | 312 | In Stock |
|
| 100MG | 475 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameUV0155041
-
NoteResearch use only, not for human use.
-
Brief DescriptionUV0155041 is an effective and positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50: 798/693 nM, at human/rat).
-
DescriptionUV0155041 is a potent, positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50 = 798 and 693 nM at human and rat mGlu4 receptors respectively).
-
In VitroVU0155041 (10 μM) does not affect NMDA receptor currents in striatal medium spiny neurons.
-
In VivoVU0155041 (31 nmol, 93 nmol; i.c.v.) reverses catalepsy induced by the dopamine D2 receptor antagonist Haloperidol (1.5 mg/kg, i.p.) in rats.VU0155041 (93 nnmol, 316 nmol; i.c.v.) reverses Reserpine (HY-N0480)-induced akinesia in rats. Animal Model:Third ventricle cannulated (TVC) Male Sprague-Dawley rats (225-255 g) Dosage:31 nmol, 93 nmol (10 μL)Administration:Intracerebroventrical injection, after the Haloperidol (1.5 mg/kg) treatment 2 hours Result:Decreased the cataleptic effects of Haloperidol, and the effects still presented 30 min after infusion.
-
SynonymsUV0155041 | UV-0155041 | UV 0155041
-
PathwayOthers
-
TargetOther Targets
-
RecptormGluR4
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1093757-42-6
-
Formula Weight316.18
-
Molecular FormulaC14H15Cl2NO3
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (316.28 mM)
-
SMILESC1CC[C@H]([C@H](C1)C(=O)Nc1cc(cc(c1)Cl)Cl)C(=O)O
-
Chemical Namecis-2-[[(3,5-Dichlorophenyl)amino]carbonyl]cyclohexanecarboxylic acid
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Niswender CM, et al. Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. Mol Pharmacol. 2008 Nov;74(5):1345-58.
molnova catalog
related products
-
Opc 18750
Opc 18750 is a compound with selective and positive inotropic effects.
-
INI-43
INI-43, an inhibitor of Nuclear Import-43, shows a significant cytotoxic effect on various cervical and oesophageal cancer cell lines by targeting Kpnβ1 and interferes with the nuclear localization of Kpnβ1 and known Kpnβ1 cargoes, NFAT, NFκB, AP-1 and NF.
-
Sophoflavescenol
Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , these effects might contribute to the antitumor activity without severe side effects.
