UNC2881 ( UNC2881, UNC-2881, UNC 2881 )

Catalog No. M17322 CAS No. 1493764-08-1

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HNMR

HPLC

MSDS

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Product Name

UNC2881
Note

Research use only, not for human use.
Brief Description

UNC2881 is a specific Mer tyrosine kinase inhibitor (IC50: 4.3 nM). It is about 83- and 58-fold higher selectivity than Axl and Tyro3, respectively.
Description

UNC2881 is a potent Mer kinase inhibitor. UNC2281 inhibits steady-state Mer kinase phosphorylation with an IC50 value of 22 nM. Treatment with UNC2281 is also sufficient to block EGF-mediated stimulation of a chimeric receptor containing the intracellular domain of Mer fused to the extracellular domain of EGFR. In addition, UNC2881 potently inhibits collagen-induced platelet aggregation, suggesting that this class of inhibitors may have utility for prevention and/or treatment of pathologic thrombosis.
Synonyms

UNC2881, UNC-2881, UNC 2881
Pathway

Endocrinology/Hormones
Target

AChR
Recptor

AXL; Mer; Tyro3
Research Area

Cardiovascular Disease
Indication

——

CAS Number

1493764-08-1
Formula Weight

463.58
Molecular Formula

C25H33N7O2
Purity

98%
Solubility

DMSO : ≥ 44 mg/mL; 94.91 mM
SMILES

CCCCNc1ncc(c(N[C@@H]2CC[C@H](CC2)O)n1)C(=O)NCc1ccc(n2ccnc2)cc1
Chemical Name

N-(4-(1H-imidazol-1-yl)benzyl)-2-(butylamino)-4-(((1r,4r)-4-hydroxycyclohexyl)amino)pyrimidine-5-carboxamide

1. Zhang W, et al. J Med Chem. 2013, 56(23), 9693-9700.

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