Cart
sales@molnova.com
UNC-0642
CAS No. 1481677-78-4
UNC-0642( AHU-377 )
Catalog No. M17319 CAS No. 1481677-78-4
UNC0642 is an effective and specific G9a/GLP inhibitor (IC50< 2.5 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 43 | In Stock |
|
| 5MG | 71 | In Stock |
|
| 10MG | 120 | In Stock |
|
| 25MG | 219 | In Stock |
|
| 50MG | 357 | In Stock |
|
| 100MG | 537 | In Stock |
|
| 200MG | 781 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameUNC-0642
-
NoteResearch use only, not for human use.
-
Brief DescriptionUNC0642 is an effective and specific G9a/GLP inhibitor (IC50< 2.5 nM).
-
DescriptionUNC0642 is a potent, selective inhibitor of G9a/GLP with improved PK properties. UNC0642 exhibits an in vitro IC50 <15 nM with selectivity > 100-fold over 13 other HMTs and selected representatives of kinases, ion channels, 7TMs, and other epigenetic proteins. In cells, UNC0642 results in a potent reduction of H3K9me2 in MDA MB231 cells with IC50 = 106 nM.
-
In Vitro——
-
In Vivo——
-
SynonymsAHU-377
-
PathwayAutophagy
-
TargetSigma receptor
-
RecptorG9a/GLP
-
Research AreaOthers-Field
-
Indication——
Chemical Information
-
CAS Number1481677-78-4
-
Formula Weight546.69
-
Molecular FormulaC29H44F2N6O2
-
Purity>98% (HPLC)
-
SolubilityDMSO : 295 mg/mL. 539.60 mM;
-
SMILESCC(N1CCC(Nc2c3cc(OC)c(OCCCN4CCCC4)cc3nc(N3CCC(F)(F)CC3)n2)CC1)C
-
Chemical Name2-(4,4-Difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Liu F, et al. Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP. J Med Chem. 2013 Nov 14;56(21):8931-42. doi: 10.1021/jm401480r. Epub 2013 Oct 31.
molnova catalog
related products
-
S1RA hydrochloride
A potent and selective sigma-1 receptor antagonist with Ki of 17 nM; shows excellent selectivity over sigma-2 receptor (Ki>1 uM).
-
BD1063
BD1063 is a potent and selective sigma 1(σ1) receptor antagonist(Ki = 9 nM).
-
KSK67
KSK67 is a selective dual antagonist of sigma-2 and histamine H3 receptors with inhibitory effects on H3 receptors, sigma-1, and sigma-2 receptors, with Ki values of 3.2, 1531, and 101 nM, respectively.
