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UK-396082
CAS No. 400044-47-5
UK-396082( UK 396,082 | UK396082 )
Catalog No. M14370 CAS No. 400044-47-5
UK-396082 is a potent and selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (activated TAFI; TAFIa) with Ki of 10 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 963 | Get Quote |
|
| 50MG | 1962 | Get Quote |
|
| 100MG | 2520 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameUK-396082
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NoteResearch use only, not for human use.
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Brief DescriptionUK-396082 is a potent and selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (activated TAFI; TAFIa) with Ki of 10 nM.
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DescriptionUK-396082 is a potent and selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (activated TAFI; TAFIa) with Ki of 10 nM; displays excellent selectivity over plasma carboxypeptidase N (>1,000-fold); exhibits antithrombotic efficacy in a rabbit model of venous thrombosis, yet has no effect on surgical bleeding in the rabbit; possesses excellent preclinical and clinical pharmacokinetic profile, and shows potential for the treatment of thrombosis and other fibrin-dependent diseases in humans.Thrombosis Phase 1 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsUK 396,082 | UK396082
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PathwayOthers
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TargetOther Targets
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RecptorOther Targets
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Research AreaCardiovascular Disease
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IndicationThrombosis
Chemical Information
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CAS Number400044-47-5
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Formula Weight239.319
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Molecular FormulaC12H21N3O2
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Purity>98% (HPLC)
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Solubility——
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SMILESCCCN1C=C(N=C1)C[C@H](CCCN)C(=O)O
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Chemical Name(S)-5-amino-2-((1-propyl-1H-imidazol-4-yl)methyl)pentanoic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Bunnage ME, et al. J Med Chem. 2007 Nov 29;50(24):6095-103.
2. Atkinson JM, et al. Matrix Biol. 2013 Jun 24;32(5):277-87.
3. Bridge K, et al. PLoS One. 2017 May 4;12(5):e0177117.
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