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UK-396082

CAS No. 400044-47-5

UK-396082( UK 396,082 | UK396082 )

Catalog No. M14370 CAS No. 400044-47-5

UK-396082 is a potent and selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (activated TAFI; TAFIa) with Ki of 10 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    UK-396082
  • Note
    Research use only, not for human use.
  • Brief Description
    UK-396082 is a potent and selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (activated TAFI; TAFIa) with Ki of 10 nM.
  • Description
    UK-396082 is a potent and selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (activated TAFI; TAFIa) with Ki of 10 nM; displays excellent selectivity over plasma carboxypeptidase N (>1,000-fold); exhibits antithrombotic efficacy in a rabbit model of venous thrombosis, yet has no effect on surgical bleeding in the rabbit; possesses excellent preclinical and clinical pharmacokinetic profile, and shows potential for the treatment of thrombosis and other fibrin-dependent diseases in humans.Thrombosis Phase 1 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    UK 396,082 | UK396082
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Other Targets
  • Research Area
    Cardiovascular Disease
  • Indication
    Thrombosis

Chemical Information

  • CAS Number
    400044-47-5
  • Formula Weight
    239.319
  • Molecular Formula
    C12H21N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCCN1C=C(N=C1)C[C@H](CCCN)C(=O)O
  • Chemical Name
    (S)-5-amino-2-((1-propyl-1H-imidazol-4-yl)methyl)pentanoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bunnage ME, et al. J Med Chem. 2007 Nov 29;50(24):6095-103. 2. Atkinson JM, et al. Matrix Biol. 2013 Jun 24;32(5):277-87. 3. Bridge K, et al. PLoS One. 2017 May 4;12(5):e0177117.
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