UCPH-101( UCPH-101, UCPH 101, UCPH101 )

Catalog No. M17146 CAS No. 1118460-77-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

UCPH-101
Note

Research use only, not for human use.
Brief Description

UCPH-101 is an?inhibitor of excitatory amino acid transporter subtype 1?(EAAT1) with an?IC50?of 0.66 μM.
Description

UCPH-101 is a selective excitatory amino acid transporter subtype?1 (EAAT1) inhibitor.
In Vitro

UCPH-101 and UCPH-102 inhibit EAAT1 anion currents in a concentration-dependent manner, with KD values of 0.34±0.03 μM (Hill=1.3±0.13, n≥9) for UCPH-101 and 0.17±0.02 μM (Hill=0.97±0.11, n≥7) for UCPH-102. A small but significant decrease in the total expression levels of both HA-EAAT1 and HA-GLAST is observed in cells preincubated with 100 μM UCPH-101 (p=0.048).
In Vivo

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Synonyms

UCPH-101, UCPH 101, UCPH101
Pathway

Others
Target

Other Targets
Recptor

EAAT1
Research Area

Neurological Disease
Indication

——

CAS Number

1118460-77-7
Formula Weight

422.48
Molecular Formula

C27H22N2O3
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 110 mg/mL 260.37 mM
SMILES

COC1=CC=C(C=C1)C2C(=C(OC3=C2C(=O)CC(C3)C4=CC=CC5=CC=CC=C54)N)C#N
Chemical Name

2-amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile

1. Abrahamsen B, et al. J Neurosci. 2013 Jan 16;33(3):1068-87.

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