
UCM-1336
CAS No. 1621535-90-7
UCM-1336( 3,3′-(Octylimino)bis[N-phenylpropanamide] )
Catalog No. M28970 CAS No. 1621535-90-7
UCM-1336 is a potent ICMT inhibitor with an IC50 of 2 μM which is selective against the other enzymes involved in the post-translational modifications of Ras.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 393 | Get Quote |
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10MG | 581 | Get Quote |
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25MG | 888 | Get Quote |
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50MG | 1242 | Get Quote |
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100MG | 1674 | Get Quote |
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500MG | 3348 | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameUCM-1336
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NoteResearch use only, not for human use.
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Brief DescriptionUCM-1336 is a potent ICMT inhibitor with an IC50 of 2 μM which is selective against the other enzymes involved in the post-translational modifications of Ras.
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DescriptionUCM-1336 is a potent ICMT inhibitor with an IC50 of 2 μM which is selective against the other enzymes involved in the post-translational modifications of Ras.(In Vitro):UCM-1336 significantly impairs the membrane association of the four Ras isoforms, leading to a decrease of Ras activity and to inhibition of Ras downstream signaling pathways. UCM-1336 induces cell death in a variety of Ras-mutated tumor cell lines and increases survival in an in vivo model of acute myeloid leukemia. Because ICMT inhibition impairs the activity of the four Ras isoforms regardless of its activating mutation, UCM-1336 surmounts many of the common limitations of available Ras inhibitors described so far.(In Vivo):UCM-1336 significantly inhibits glioblastoma growth without causing toxicity in mice.
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In Vitro——
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In Vivo——
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Synonyms3,3′-(Octylimino)bis[N-phenylpropanamide]
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PathwayOthers
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TargetOther Targets
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number1621535-90-7
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Formula Weight423.59
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Molecular FormulaC26H37N3O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (236.08 mM)
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SMILESCCCCCCCCN(CCC(Nc1ccccc1)=O)CCC(Nc1ccccc1)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Wang X, et al. Phenylboronic Acid-Mediated Tumor Targeting of Chitosan Nanoparticles. Theranostics. 2016 Jun 15;6(9):1378-92.
molnova catalog



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