UCB-9260

Research use only, not for human use.

UCB-9260 inhibits TNF signaling by stabilizing an asymmetric form of the trimer.

UCB-9260 inhibits TNF signaling by stabilizing an asymmetric form of the trimer.(In Vitro):UCB-9260 (0-10 μM) inhibits NF-κB with a geometric mean IC50 of 202 nM after TNF (10 pM) stimulation in in Hek-293 cells.UCB-9260 inhibits TNF-dependent cytotoxicity with a geometric mean IC50 of 116 nM and a geometric mean IC50 of 120 nM, using human and mouse TNF, respectively.(In Vivo):UCB-9260 (0-10 μM) inhibits NF-κB with a geometric mean IC50 of 202 nM after TNF (10 pM) stimulation in in Hek-293 cells.UCB-9260 inhibits TNF-dependent cytotoxicity with a geometric mean IC50 of 116 nM and a geometric mean IC50 of 120 nM, using human and mouse TNF, respectively.

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Animal Model:Aged 6-8 weeks adult male Balb/c mice?(?CAIA model) Dosage:150?mg/kg Administration:p.o.; twice daily for 7days?Result:Showed a significant reduction of the clinical score.

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Apoptosis

TNF

TNF

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1515888-53-5

423.51

C26H25N5O

>98% (HPLC)

DMSO:10 mM

OC(C1=CC=NC=C1)C2=NC3=CC=C(C4=CN(C)N=C4)C=C3N2CC5=CC(C)=CC=C5C

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(-20℃)

With Ice Pack

≥ 2 years