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Home - Products - MAPK/ERK Signaling - Ras - UC-773587

UC-773587

CAS No. 116679-69-7

UC-773587( UC 773587;UC773587 )

Catalog No. M10570 CAS No. 116679-69-7

A small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=3.4 uM) and disrupts GEF-Ras interaction.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    UC-773587
  • Note
    Research use only, not for human use.
  • Brief Description
    A small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=3.4 uM) and disrupts GEF-Ras interaction.
  • Description
    A small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=3.4 uM) and disrupts GEF-Ras interaction; dose-dependently disrupts the SOS1-Ras interaction by competitively inhibiting the binding of SOS1cat to GDP-bound H-Ras in a microscale thermophoresis assay; dose-dependently inhibits Ras activation and downstream ERK activation mediated through EGFR-SOS1-Ras-Raf1-MEK-ERK signaling, specifically inhibits wild-type mouse embryonic fibroblast growth but not the growth of oncogenic H-Ras(G12V)-expressing mouse embryonic fibroblasts; inhibits Ras signaling and growth of pancreatic and prostate cancer cells.
  • Synonyms
    UC 773587;UC773587
  • Pathway
    MAPK/ERK Signaling
  • Target
    Ras
  • Recptor
    Ras
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    116679-69-7
  • Formula Weight
    432.43
  • Molecular Formula
    C28H16O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    2-(11-hydroxy-3-oxo-3H-dibenzo[c,h]xanthen-7-yl)benzoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Evelyn CR, et al. J Biol Chem. 2015 May 15;290(20):12879-98.
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