UC-1728

CAS No. 948304-40-3

UC-1728 ( t-TUCB )

Catalog No. M22948 CAS No. 948304-40-3

UC-1728 is an effective rabbit soluble epoxide hydrolase inhibitor (IC50: 2 nM on rabbit liver). Rabbits were treated by subcutaneous injection with the sEH inhibitor (UC1728, 3 mg/kg), or the vehicle control (PEG400) and uveitis was assessed at 6, 24 and 48 h post-intracameral LPS injection using a modified Hackett-McDonald scoring system.?

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 272 In Stock
10MG 408 In Stock
25MG 672 In Stock
50MG 945 In Stock
100MG 1278 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    UC-1728
  • Note
    Research use only, not for human use.
  • Brief Description
    UC-1728 is an effective rabbit soluble epoxide hydrolase inhibitor (IC50: 2 nM on rabbit liver). Rabbits were treated by subcutaneous injection with the sEH inhibitor (UC1728, 3 mg/kg), or the vehicle control (PEG400) and uveitis was assessed at 6, 24 and 48 h post-intracameral LPS injection using a modified Hackett-McDonald scoring system.?
  • Description
    UC-1728 is an effective rabbit soluble epoxide hydrolase inhibitor (IC50: 2 nM on rabbit liver). Rabbits were treated by subcutaneous injection with the sEH inhibitor (UC1728, 3 mg/kg), or the vehicle control (PEG400) and uveitis was assessed at 6, 24 and 48 h post-intracameral LPS injection using a modified Hackett-McDonald scoring system.?Eyes treated by intra-cameral injection of PBS, or by aseptic preparation served as further controls.?Signs of inflammation in this model were mild and transient.?Treatment with UC1728 did not significantly reduce inflammation compared to animals treated with the PEG400 vehicle.?Blood levels of UC1728 were a thousand fold higher than the in vitro determined inhibitory potency (IC50) of the compound suggesting a significant degree of inhibition of sEH in the rabbit.?The lack of efficacy suggests that sEH or its substrates the EETs may not be involved in mediating inflammation in this model of uveitis.
  • Synonyms
    t-TUCB
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    epoxide hydrolase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    948304-40-3
  • Formula Weight
    438.4
  • Molecular Formula
    C21H21F3N2O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    FC(F)(F)OC(C=C1)=CC=C1NC(N[C@@H](CC2)CC[C@H]2OC3=CC=C(C(O)=O)C=C3)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. McLellan GJ, et al. Effect of a Soluble Epoxide Hydrolase Inhibitor, UC1728, on LPS-Induced Uveitis in the Rabbit. J Ocul Biol. 2016 Jan;4(1).
molnova catalog
related products
  • Bavachin

    Bavachin is a phytoestrogen that activates the estrogen receptors ERα and ERβ.

  • 2,3-Dichloroanisole

    Substituted aminosalicylic acid amides with fungicidal effect and intermediate products.

  • Acetanilide

    Acetanilide is an aniline derivative and has possess analgesic.