Tylosin( —— )

Catalog No. M11676 CAS No. 1401-69-0

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Datasheet

HNMR

HPLC

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Product Name

Tylosin
Note

Research use only, not for human use.
Brief Description

Tylosin (Fradizine; Tylocine; Tylosin A) is a broad spectrum antibiotic against Gram-positive organisms and a limited range of Gram-negative organisms.
Description

Tylosin (Fradizine; Tylocine; Tylosin A) is a broad spectrum antibiotic against Gram-positive organisms and a limited range of Gram-negative organisms.
In Vitro

Tylosin exerts antibacterial effects by binding to 23S rRNA of the bacterial ribosomal 50S subunit .Tylosin also prevents growth of Gram-negative strains, with MICs of 64 μg/mL, 32 μg/mL, 512 μg/mL and 1 μg/mL for M. haemolytica 11935, P. multocida 4407, E. coli ATCC 25922 and E. coli AS19rlmAI, respectively.
In Vivo

Tylosin (10-500 mg/kg; s.c.) generally suppresses the elevated TNF-α and IL-1β levels and increases the IL-10 levels in the Lipopolysaccharide (LPS) -treated animals. Animal Model:Balb/C mice (2-3 months old, 20-25 g)Dosage:10 mg/kg, 100 mg/kg, 500 mg/kg Administration:Subcutaneous injection Result:Reduced the elevated TNF-α and IL-1β in LPS (250 μg)-treated mice but increased their IL-10 levels.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Infection
Indication

——

CAS Number

1401-69-0
Formula Weight

916.1
Molecular Formula

C46H77NO17
Purity

>98% (HPLC)
Solubility

Soluble in DMSO
SMILES

CC[C@@H]1[C@H](/C=C(/C=C/C(=O)[C@@H](C[C@@H]([C@@H]([C@H]([C@@H](CC(=O)O1)O)C)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C)O[C@H]3C[C@@]([C@H]([C@@H](O3)C)O)(C)O)N(C)C)O)CC=O)C)\C)CO[C@H]4[C@@H]([C@@H]([C@@H]([C@H](O4)C)O)OC)OC
Chemical Name

——

1.Kolanovi? BS, et al. J Immunoassay Immunochem. 2014;35(1):37-47.

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