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Triclopyr

CAS No. 55335-06-3

Triclopyr( —— )

Catalog No. M33706 CAS No. 55335-06-3

Triclopyr (NSC 190671) is a synthetic growth hormone-like herbicide and fungicide that is cytotoxic, induces mitochondrial damage in rat liver, and is widely used in agricultural research.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Triclopyr
  • Note
    Research use only, not for human use.
  • Brief Description
    Triclopyr (NSC 190671) is a synthetic growth hormone-like herbicide and fungicide that is cytotoxic, induces mitochondrial damage in rat liver, and is widely used in agricultural research.
  • Description
    Triclopyr, a foliar systemic herbicide and fungicide, is widely used for broadleaf and woody plant control. Triclopyr has severe toxicity.
  • In Vitro
    Triclopyr (3 mM; 48 hours) treatment exhibits cytotoxicity against N2a cells.Cell Cytotoxicity Assay Cell Line:Mouse neuroblastoma (N2a) cells Concentration:3 mM Incubation Time:48 hours Result:Decreased significantly for cell viability (P < 0.0001) compared to the untreated N2a cells.
  • In Vivo
    Pharmacokinetic Analysis Triclopyr exhibits moderate half-lives (dog 25 h and monkey 6.3 h) due to plasma clearance (18 mL/h/kg, 26 mL/h/kg respectively) following oral gavage (3 male beagle dogs ;0.5 mg/kg, 5 mg/kg and 20 mg/kg) and intravenous administration (1 male rhesus monkey; 30 mg/kg) .Animal Model:3 male beagle dogs(7.2 - 7.9 kg), 1 male rhesus monkey Dosage:0.5 mg/kg, 5 mg/kg, 20 mg/kg (beagle dog); 30 mg/kg (rhesus monkey) Administration:Oral gavage (beagle dog); intravenous (rhesus monkey)Result:T1/2s of 25 and 6.3 h for dogs and a monkey, respectively.
  • Synonyms
    ——
  • Pathway
    Microbiology/Virology
  • Target
    Antifungal
  • Recptor
    Antifungal
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    55335-06-3
  • Formula Weight
    256.47
  • Molecular Formula
    C7H4Cl3NO3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(O)COC1=NC(Cl)=C(Cl)C=C1Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tejaswini P Reddy, et al. Toxicity of neurons treated with herbicides and neuroprotection by mitochondria-targeted antioxidant SS31. Int J Environ Res Public Health. 2011 Jan;8(1):203-21.?
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