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Tretazicar
CAS No. 21919-05-1
Tretazicar( CB1954 | CB-1954 | CB 1954 | Tretazicar )
Catalog No. M18246 CAS No. 21919-05-1
CB1954(Tretazicar), an anticancer prodrug, is activated by NAD(P)H quinone oxidoreductase 2.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 42 | In Stock |
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| 10MG | 65 | In Stock |
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| 25MG | 132 | In Stock |
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| 50MG | 200 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameTretazicar
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NoteResearch use only, not for human use.
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Brief DescriptionCB1954(Tretazicar), an anticancer prodrug, is activated by NAD(P)H quinone oxidoreductase 2.
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DescriptionTretazicar (CB1954) is a dinitrobenzamide prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent. CB1954 has been proposed for use in enzyme-prodrug gene therapy systems with the Escherichia coli enzyme nitroreductase (Ntr). Ntr converts CB1954 to 2- and 4-hydroxylamino derivatives, whereupon the non-enzymatic reaction of the 4-hydroxylamino derivative with cellular thio- esters generates a potent cytotoxic bifunctional alkylating agent capable of cross-linking DNA.
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In Vitro——
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In VivoAnimal Model:Female BALB/c mice (AB22-nr, SKOV3 human ovarian tumour xenograft)Dosage:80 mg/kg Administration:i.p. on days 2 and 9 Result:The median survival of the AB22-nr was 49 days. Resulted in a significant increase in survival.
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SynonymsCB1954 | CB-1954 | CB 1954 | Tretazicar
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PathwayPI3K/Akt/mTOR signaling
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TargetmTOR
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RecptorDNA alkylator
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number21919-05-1
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Formula Weight252.18
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Molecular FormulaC9H8N4O5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (495.68 mM)
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SMILESNC(=O)c1c(cc(c(c1)N1CC1)[N+](=O)[O-])[N+](=O)[O-]
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Chemical Name5-(aziridin-1-yl)-2,4-dinitrobenzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Gui R,etal.Inhibition of Grb2-mediated activation of MAPK signal transduction suppresses NOR1/CB1954-induced cytotoxicity in the HepG2 cell line.Oncol Lett. 2012 Sep;4(3):566-570.
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Tretazicar
CB1954(Tretazicar), an anticancer prodrug, is activated by NAD(P)H quinone oxidoreductase 2.
