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Toyocamycin

CAS No. 606-58-6

Toyocamycin ( Vengicide )

Catalog No. M22947 CAS No. 606-58-6

Toyocamycin is an adenosine analog produced by Actinomycete, acts as an XBP1 inhibitor, inhibits IRE1α-induced ATP-dependent XBP1 mRNA cleavage (IC50: 80 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 53 In Stock
25MG 104 In Stock
50MG 192 In Stock
100MG 335 In Stock
500MG 782 In Stock
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Biological Information

  • Product Name
    Toyocamycin
  • Note
    Research use only, not for human use.
  • Brief Description
    Toyocamycin is an adenosine analog produced by Actinomycete, acts as an XBP1 inhibitor, inhibits IRE1α-induced ATP-dependent XBP1 mRNA cleavage (IC50: 80 nM).
  • Description
    Toyocamycin is an adenosine analog produced by Actinomycete, acts as an XBP1 inhibitor, inhibits IRE1α-induced ATP-dependent XBP1 mRNA cleavage (IC50: 80 nM). Toyocamycin induces apoptosis.
  • Synonyms
    Vengicide
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    XBP1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    606-58-6
  • Formula Weight
    291.26
  • Molecular Formula
    C12H13N5O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:100 mg/mL (343.34 mM; Need ultrasonic)
  • SMILES
    O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C3=C(C(N)=NC=N3)C(C#N)=C2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Toyocamycin, et al. Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing. Blood Cancer J. 2012 Jul;2(7):e79.
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