Toyocamycin ( Vengicide )

Catalog No. M22947 CAS No. 606-58-6

Toyocamycin is an adenosine analog produced by Actinomycete, acts as an XBP1 inhibitor, inhibits IRE1α-induced ATP-dependent XBP1 mRNA cleavage (IC50: 80 nM).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
5MG	35	In Stock
10MG	53	In Stock
25MG	104	In Stock
50MG	192	In Stock
100MG	335	In Stock
500MG	782	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

Toyocamycin
Note

Research use only, not for human use.
Brief Description

Toyocamycin is an adenosine analog produced by Actinomycete, acts as an XBP1 inhibitor, inhibits IRE1α-induced ATP-dependent XBP1 mRNA cleavage (IC50: 80 nM).
Description

Toyocamycin is an adenosine analog produced by Actinomycete, acts as an XBP1 inhibitor, inhibits IRE1α-induced ATP-dependent XBP1 mRNA cleavage (IC50: 80 nM). Toyocamycin induces apoptosis.
Synonyms

Vengicide
Pathway

Others
Target

Other Targets
Recptor

XBP1
Research Area

——
Indication

——

Chemical Information

CAS Number

606-58-6
Formula Weight

291.26
Molecular Formula

C12H13N5O4
Purity

>98% (HPLC)
Solubility

DMSO:100 mg/mL (343.34 mM; Need ultrasonic)
SMILES

O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C3=C(C(N)=NC=N3)C(C#N)=C2
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Toyocamycin, et al. Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing. Blood Cancer J. 2012 Jul;2(7):e79.

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